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Morphine Analgesia in Patients With Acute Appendicitis

This study has been completed.
Sponsor:
Information provided by:
Tehran University of Medical Sciences
ClinicalTrials.gov Identifier:
NCT00477061
First received: May 20, 2007
Last updated: NA
Last verified: May 2007
History: No changes posted
  Purpose

The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.


Condition Intervention Phase
Appendicitis
Drug: Morphine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double-Blind
Primary Purpose: Supportive Care
Official Title: Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis

Resource links provided by NLM:


Further study details as provided by Tehran University of Medical Sciences:

Primary Outcome Measures:
  • Pain Intensity

Secondary Outcome Measures:
  • Diagnostic Accuracy

Enrollment: 71
Study Start Date: January 2004
Study Completion Date: March 2005
Detailed Description:

Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.

Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.

  Eligibility

Ages Eligible for Study:   13 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • clinical signs of acute appendicitis
  • planned for appendectomy
  • supposed to wait for at least 1 hour in the ED before operation

Exclusion Criteria:

  • suspicion to perforated appendicitis
  • being under the age of 13
  • pregnancy (according to history and ß-HCG result)
  • opium addiction
  • systolic blood pressure of less than 90 mmHG
  • known cases of chronic obstructive pulmonary disease (COPD)
  • known sensitivity to morphine
  • history of sickle cell disease
  • self administration of analgesics before enrollment
  • refusal to participate
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00477061

Locations
Iran, Islamic Republic of
Sina General Hospital
Tehran, Iran, Islamic Republic of
Sponsors and Collaborators
Tehran University of Medical Sciences
Investigators
Principal Investigator: Asieh Golozar, MD Tehran University of Medical Sciences
  More Information

No publications provided by Tehran University of Medical Sciences

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00477061     History of Changes
Other Study ID Numbers: AG11
Study First Received: May 20, 2007
Last Updated: May 20, 2007
Health Authority: Iran: Ministry of Health

Keywords provided by Tehran University of Medical Sciences:
MORPHINE
ANALGESIA
ACUTE APPENDICITS

Additional relevant MeSH terms:
Acute Disease
Appendicitis
Cecal Diseases
Digestive System Diseases
Disease Attributes
Gastroenteritis
Gastrointestinal Diseases
Infection
Intestinal Diseases
Intraabdominal Infections
Pathologic Processes
Morphine
Analgesics
Analgesics, Opioid
Central Nervous System Agents
Central Nervous System Depressants
Narcotics
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Sensory System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on November 20, 2014