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Correlation of Hyperghrelinemia With Carotid Artery Intima-Media Thickness in Children With Prader-Willi Syndrome

This study has been completed.
Sponsor:
Information provided by:
Samsung Medical Center
ClinicalTrials.gov Identifier:
NCT00474643
First received: May 10, 2007
Last updated: May 15, 2007
Last verified: May 2007
History of Changes
  Purpose

Prader-Willi syndrome (PWS) is a genetic disorder characterized by childhood-onset obesity and endocrine dysfunction that leads to cardiovascular disability and early death within the first 3 decades of life.To assess the significance of risk factors for future disabilities, carotid artery intima-media thickness (IMT) was measured and correlated with known atherosclerotic risk factors in 27 children with PWS and 24 age-, sex-, and body mass index (BMI)-adjusted controls.


Condition
Prader Willi Syndrome
Obesity

Study Type: Observational
Study Design: Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Samsung Medical Center:

Enrollment: 51
Study Start Date: August 2006
Study Completion Date: December 2006
Detailed Description:

Main outcome measures: Correlation of IMT with age, standard deviation score of BMI (BMI-SDS), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), C-reactive protein, HOMA-IR and ghrelin.

  Eligibility

Ages Eligible for Study:   1 Year to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Prader Willi syndrome
  • Children with obesity

Exclusion Criteria:

  • Acute illness
  • On regular medications except growth hormone
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00474643

Sponsors and Collaborators
Samsung Medical Center
Investigators
Principal Investigator: Kyung Hoon Paik, M.D. Samsung Medical Center, Sungkyunkwan University School of Medicine
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00474643     History of Changes
Other Study ID Numbers: 2006-06-043
Study First Received: May 10, 2007
Last Updated: May 15, 2007
Health Authority: South Korea: Institutional Review Board

Additional relevant MeSH terms:
Obesity
Prader-Willi Syndrome
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms
Mental Retardation
 Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Abnormalities, Multiple
Congenital Abnormalities
Chromosome Disorders
Genetic Diseases, Inborn

ClinicalTrials.gov processed this record on June 17, 2013