Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

This study is currently recruiting participants.

Verified October 2011 by University of British Columbia

First Received on May 14, 2007. Last Updated on October 19, 2011 History of Changes

Sponsor:	University of British Columbia
Collaborators:	National Institutes of Health (NIH) Shriners Hospitals for Children
Information provided by (Responsible Party):	University of British Columbia
ClinicalTrials.gov Identifier:	NCT00474344

Purpose

The goal of this study is to identify and characterize the genetic loci causing idiopathic talipes equinovarus (clubfoot).

The hypothesis is that a few genes account for a substantial fraction of ITEV and that these genes can be identified in defined populations. Towards this goal, in preliminary studies, Dr. Hecht's group has identified two genes, NAT2 and CASP10, which demonstrate evidence for linkage and association to ITEV.

Condition
Clubfoot

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Retrospective
Official Title:	Genetic Linkage Study of Idiopathic Talipes Equinovarus (ITEV) (Clubfoot)

Resource links provided by NLM:

Genetics Home Reference related topics: Help Me Understand Genetics

U.S. FDA Resources

Further study details as provided by University of British Columbia:

Estimated Enrollment:	500
Study Start Date:	August 2004
Estimated Study Completion Date:	December 2011

Detailed Description:

Blood Collection: For this study, the investigators need to obtain blood samples from members of families in which clubfoot has occurred; more specifically, blood samples from the affected child and both parents. DNA will be extracted from blood samples. The DNA will then be tested to look for genetic factors that cause clubfoot.

Study Questionnaires: As well as the blood samples, the investigators have a short questionnaire for the mother of the child with clubfoot to complete.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

One family member, usually child, must have clubfoot.

Criteria

Inclusion Criteria:

One family member, usually child, must have clubfoot

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00474344

Contacts

Contact: Harpreet Chhina, MSC	604-875-2000 ext 6008	hchhina@cw.bc.ca
Contact: Harpreet Chhina	605-875-2000 ext 6008	hchhina@cw.bc.ca

Locations

United States, Texas
University of Texas	Recruiting
Houston, Texas, United States
Contact: Harpreet Chhina, MSC 604-875-2000 ext 6008 hchhina@cw.bc.ca
Canada, British Columbia
BC Children's Hospital	Recruiting
Vancouver, British Columbia, Canada, V6H 3V4
Contact: Harpreet Chhina, MSC 604-875-2000 ext 6008 hchhina@cw.bc.ca

Sponsors and Collaborators

University of British Columbia

National Institutes of Health (NIH)

Shriners Hospitals for Children

Investigators

Principal Investigator:

Christine Alvarez, MD

University of British Columbia

More Information

No publications provided

Responsible Party:	University of British Columbia
ClinicalTrials.gov Identifier:	NCT00474344 History of Changes
Other Study ID Numbers:	H04-70319
Study First Received:	May 14, 2007
Last Updated:	October 19, 2011
Health Authority:	Canada: Health Canada

Keywords provided by University of British Columbia:

Genetics
Clubfoot
DNA
Idiopathic Talipes Equinovarus also known as Clubfoot

Additional relevant MeSH terms:

Clubfoot
Equinus Deformity
Foot Deformities, Congenital

Foot Deformities
Musculoskeletal Diseases
Foot Deformities, Acquired

ClinicalTrials.gov processed this record on February 09, 2012