Aortic Balloon Counterpulastion in Myocardial Infarction Related Shock (IABPSHOCK)
The role of intra aortic balloon counterpulsation in patients experiencing acute myocardial infarction with shock is not established. We hypothesised that use of such a device would lead to improved outcomes in these patients.
Device: Intra-aortic balloon pump counterpulsation
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Intra-Aortic Balloon Counterpulsation in Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock - The Prospective, Randomised IABP SHOCK Trial for Attenuation of Multi-Organ Dysfunction Syndrome|
- APACHE II SCORE [ Time Frame: 4 days ]
- Haemodynamic state [ Time Frame: 4 days ]
- BNP levels [ Time Frame: 4 days ]
- Inflammatory activation [ Time Frame: 4 days ]
- Mortality [ Time Frame: 4 days ]
|Study Start Date:||March 2003|
|Study Completion Date:||June 2004|
Patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) with cardiogenic shock (CS) are often treated with Intra-aortic balloon pump counterpulsation (IABP) although the evidence to support this is limited. We conducted a prospective, randomised clinical trial, of IABP as an addition to PCI centred therapy, in patients with AMI complicated by CS.
45 patients with AMI and CS undergoing PCI were randomised to care with or without IABP. Over 4 days, APACHE II scores, haemodynamic parameters, inflammatory markers and BNP levels were collected to assess the impact of IABP treatment on CS triggered multi organ dysfunction syndrome (MODS).
Please refer to this study by its ClinicalTrials.gov identifier: NCT00469248
|Department of Medicine III, Klinikum Krollwitz, Martin Luther University|
|Halle (Saale), Saxony - Anhalt, Germany, 06120|
|Study Chair:||Michael Buerke, MD||Martin Luther University|
|Principal Investigator:||Roland Prondzinsky, MD||Martin Luther University|