Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS

This study has been completed.

Sponsor:

Information provided by:

Ziv Hospital

ClinicalTrials.gov Identifier:

NCT00466050

First received: April 25, 2007

Last updated: August 23, 2009

Last verified: April 2007

History of Changes

Purpose

Thirty patients scheduled to coronary angiography and IVUS in according to their treating physician decision will be enrolled in the study. The coronary angiography and IVUS will be done on according to regular clinical standards.

As the study protocol, 40 cc of blood will be drawn from the patients after written informed consent.

The laboratory tests will be processed for the above mentioned serum markers of unstable plaque.

A multivariate correlation test will be done between the different serum markers and the plaque morphology by angiography and composition (virtual histology) by IVUS.

Condition
Acute Coronary Thrombose Plaque Rupture Acute Coronary Syndrome

Study Type:	Observational
Study Design:	Observational Model: Case-Only Time Perspective: Prospective
Official Title:	Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS

Further study details as provided by Ziv Hospital:

Estimated Enrollment:	30
Study Start Date:	April 2007
Study Completion Date:	May 2009
Primary Completion Date:	April 2008 (Final data collection date for primary outcome measure)

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

Patients scheduled to coronary angiography and IVUS

Criteria

Inclusion Criteria:

Both genders: males and females
Age - above 18 years
Patients scheduled to coronary angiography and IVUS
Written Informed Consent Form

Exclusion Criteria:

Pregnant or breast-feeding woman

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00466050

Locations

Israel
Heart Institute ,Ziv Medical Center
Safed, Israel, 13110

Sponsors and Collaborators

Ziv Hospital

Investigators

Principal Investigator:	Osamah Hussein, MD	ZIV Medical Center
Principal Investigator:	Alon Marmor, Prof	Ziv Medical Center

More Information

Publications:

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von Birgelen C, de Vrey EA, Mintz GS, Nicosia A, Bruining N, Li W, Slager CJ, Roelandt JR, Serruys PW, de Feyter PJ. ECG-gated three-dimensional intravascular ultrasound: feasibility and reproducibility of the automated analysis of coronary lumen and atherosclerotic plaque dimensions in humans. Circulation. 1997 Nov 4;96(9):2944-52.

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Cosin-Sales J, Kaski JC, Christiansen M, Kaminski P, Oxvig C, Overgaard MT, Cole D, Holt DW. Relationship among pregnancy associated plasma protein-A levels, clinical characteristics, and coronary artery disease extent in patients with chronic stable angina pectoris. Eur Heart J. 2005 Oct;26(20):2093-8. Epub 2005 Jul 29.

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Heeschen C, Dimmeler S, Fichtlscherer S, Hamm CW, Berger J, Simoons ML, Zeiher AM; CAPTURE Investigators. Prognostic value of placental growth factor in patients with acute chest pain. JAMA. 2004 Jan 28;291(4):435-41.

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Responsible Party:	Ziv Hospital
ClinicalTrials.gov Identifier:	NCT00466050 History of Changes
Other Study ID Numbers:	HP-7-234-S
Study First Received:	April 25, 2007
Last Updated:	August 23, 2009
Health Authority:	Israel: Ministry of Health

Keywords provided by Ziv Hospital:

plaque rupture,
acute coronary thrombose,
coronary angiography,
IVUS

Additional relevant MeSH terms:

Acute Coronary Syndrome
Rupture
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Angina Pectoris

Vascular Diseases
Chest Pain
Pain
Signs and Symptoms
Wounds and Injuries

ClinicalTrials.gov processed this record on May 16, 2013

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