Metabolic Effects of Cocaine

This study has been completed.

Sponsor:

Collaborator:

National Alliance for Research on Schizophrenia and Depression

Information provided by:

National Institute on Drug Abuse (NIDA)

ClinicalTrials.gov Identifier:

NCT00451230

First received: March 22, 2007

Last updated: April 30, 2013

Last verified: October 2002

History of Changes

Purpose

The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence

Condition	Intervention
Cocaine Dependence	Drug: cocaine Drug: hydrocortisone

Study Type:	Interventional
Study Design:	Allocation: Randomized Intervention Model: Single Group Assignment Masking: Double-Blind
Official Title:	Elucidating the Role of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in the Mechanisms Underlying Cocaine Dependence

Resource links provided by NLM:

MedlinePlus related topics: Diabetes Medicines

Drug Information available for: Hydrocortisone acetate Hydrocortisone Cocaine hydrochloride Hydrocortisone sodium succinate Hydrocortisone cypionate Hydrocortisone butyrate Hydrocortisone valerate Hydrocortisone probutate

U.S. FDA Resources

Further study details as provided by National Institute on Drug Abuse (NIDA):

Estimated Enrollment:

Eligibility

Ages Eligible for Study:	21 Years to 49 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Individuals with DSM IV diagnosis of cocaine dependence, medically healthy

Exclusion Criteria:

Other than cocaine dependence DSM-IV axis I diagnosis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00451230

Locations

United States, Massachusetts
Massachusetts General Hospital
Boston, Massachusetts, United States, 02116

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

National Alliance for Research on Schizophrenia and Depression

Investigators

Principal Investigator:

Igor Elman

MGH

More Information

No publications provided by National Institute on Drug Abuse (NIDA)

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Rott D, Langleben DD, Elman I. Cocaine decreases plasma insulin concentrations in non-diabetic subjects: a randomized double-blind study. Diabet Med. 2008 Apr;25(4):510-1. Epub 2008 Mar 13. No abstract available.

ClinicalTrials.gov Identifier:	NCT00451230 History of Changes
Other Study ID Numbers:	2000p 000323, DA#14410
Study First Received:	March 22, 2007
Last Updated:	April 30, 2013
Health Authority:	United States: Federal Government

Keywords provided by National Institute on Drug Abuse (NIDA):

craving, insulin, leptin

Additional relevant MeSH terms:

Cocaine-Related Disorders
Substance-Related Disorders
Mental Disorders
Cocaine
Cortisol succinate
Hydrocortisone acetate
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone
Hydrocortisone-17-butyrate
Vasoconstrictor Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Dopamine Uptake Inhibitors

Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Uptake Inhibitors
Physiological Effects of Drugs
Anesthetics, Local
Anesthetics
Central Nervous System Depressants
Sensory System Agents
Peripheral Nervous System Agents
Central Nervous System Agents
Anti-Inflammatory Agents
Dermatologic Agents

ClinicalTrials.gov processed this record on May 16, 2013

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