Kinetics of D-Dimers After Abdominal Surgery
The purpose of this study is to investigate the natural kinetics of D-dimers that occur after abdominal surgery.
Natural Kicetics of d-Dimers After Surgery
|Study Design:||Time Perspective: Prospective|
|Official Title:||The Kinetics of D-Dimers After Abdominal Surgery as a Function of the Invasiveness of Surgery|
|Study Start Date:||February 2007|
|Study Completion Date:||October 2007|
Venous thromboembolism (VTE) is a potentially fatal disease with an estimated incidence of 0.1%. One third of the VTE occur as pulmonal embolism with a mortality up to 25% (White RH. Circulation 107:2003)
Serum d-dimer levels are used as sensitive marker for the diagnosis of VTE (Kelly J et al. Arch Intern Med, 162: 2002). Because of its sensitivity, the determination of serum D-dimer levels is an accepted method to exclude VTE in the outpatient setting meaning that VTE may be excluded in case of normal D-dimer levels (Kelly J. Lancet 359: 2002). The specificity of the D-dimer testing, however, is low. This is true especially in the postoperative phase. The interpretation of elevated D-dimer levels in surgical patients remains elusive.
The natural kinetics of D-dimers after surgery is not known. The question to what extent D-dimer levels rise after surgery and how long it may take D-dimer levels to return to normal after surgery is not yet determined. This information is needed to be able to use D-dimer testing for VTE diagnosis in surgical patients.
In this study, D-dimer levels are measured in surgical patients immediately before (day 0) and repeatedly after surgery. D-dimer level measurement will be stopped after D-dimer levels returned to normal.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00450528
|Univeryity Hospital, Clinic for Visceral- and Transplantation Surgery|
|Zurich, Switzerland, 8091|
|Principal Investigator:||Daniel Dindo, MD||University of Zurich|