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Dendritic Cells in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation (DCalloTX)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2007 by Dresden University of Technology.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Dresden University of Technology
ClinicalTrials.gov Identifier:
NCT00450268
First received: March 21, 2007
Last updated: NA
Last verified: March 2007
History: No changes posted
  Purpose

We plan to investigate prospectively and simultaneously skin and blood DC subtypes, their donor/recipient origin and the correlation of DC reconstitution kinetics with treatment, clinical outcome and incidence of aGvHD in patients undergoing allogeneic hematopoietic stem cell transplantation.


Condition Intervention
Graft Versus Host Disease
 Procedure: blood draw, skin shave biopsy

Study Type: Observational
Study Design: Observational Model: Defined Population
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Analysis of Dendritic Cells in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation

Further study details as provided by Dresden University of Technology:

Estimated Enrollment: 50
Study Start Date: January 2005
Estimated Study Completion Date: January 2010
Detailed Description:

Blood and skin DC reconstitution shall be investigated in patients affected by hematological diseases and receiving HLA-matched, mobilized peripheral blood stem cells from related or unrelated donors. We plan to simultaneously collect and process double biopsies, i.e. from graft versus host disease affected and non-lesional skin of patients at onset of acute graft versus host disease following allogeneic hematopoietic stem cell transplantation. Emigration assay, Chimerism analysis and immunohistochemistry will be performed.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patient undergoing an allogeneic hematopoietic stem cell transplantation
  • Older than 18 years
  • WHO-Performance-Status 0 to3
  • Informed consent
  • Graft versus host disease of the skin

Exclusion Criteria:

  • Clotting parameters more than double of normal
  • Infection of the skin
  • Leucocytes < 1000/µl; Thrombocytes < 20 000/µl
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00450268

Contacts
Contact: Susanne Gretzinger, MD +49 351 458 ext 2583 susanne.gretzinger@uniklinik-dresden.de
Contact: Martin Bornhäuser, Professor *49 351 458 ext 4190 martin.bormhaeuser@uniklinik-dresden.de

Locations
Germany
Universitätsklinik Carl Gustav Carus Recruiting
Dresden, Germany, 01307
Contact: Susanne Gretzinger, MD     +49 351 458 ext 2583     susanne.gretzinger@uniklinik-dresden.de    
Contact: Martin Bornhaeuser, MD     +49 351 458 ext 4190     Martin.Bornhaeuser@uniklinik-dresden.de    
Principal Investigator: Susanne Gretzinger, MD            
Principal Investigator: Martin Bornhaeuser, Prof            
Principal Investigator: Christian Thiede, Prof            
Sponsors and Collaborators
Dresden University of Technology
Investigators
Principal Investigator: Susanne Gretzinger, MD Universität Carl Gustav Carus Med Klinik I
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00450268     History of Changes
Other Study ID Numbers: EK208122001
Study First Received: March 21, 2007
Last Updated: March 21, 2007
Health Authority: Germany: Ethics Commission

Keywords provided by Dresden University of Technology:
Graft versus host disease
Allogeneic hematpoietic stem cell transplantation

Additional relevant MeSH terms:
Graft vs Host Disease
Immune System Diseases

ClinicalTrials.gov processed this record on May 19, 2013