Influence of Fitness on Brain and Cognition

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by University of Illinois at Urbana-Champaign
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Arthur Kramer, University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier:
NCT00438347
First received: February 21, 2007
Last updated: March 29, 2014
Last verified: March 2014
  Purpose

The purpose of this study is to examine the effect of aerobic fitness training on human cognition, brain structure, and brain function of older adults.


Condition Intervention
Aging
Cognitive Ability, General
Behavioral: Aerobic Exercise
Behavioral: Stretching and toning

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Influence of Fitness on Brain and Cognition

Resource links provided by NLM:


Further study details as provided by University of Illinois at Urbana-Champaign:

Primary Outcome Measures:
  • Behavioral measures [ Time Frame: baseline, 6 and 12 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • fMRI [ Time Frame: baseline, 6 and 12 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 140
Study Start Date: April 2006
Estimated Study Completion Date: December 2020
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
group 1
Intervention Group- aerobic exercise
Behavioral: Aerobic Exercise
One hour per day three times a week for one year
group 2
Control Group- stretching and toning
Behavioral: Stretching and toning
One hour per day three times a week for one year

Detailed Description:

Recent studies have shown the encouraging effects of fitness training on human cognition, and brain structure and function. Such effects are of great interest both for what may they tell us about the nature of cognitive and brain aging and also for their public health implications. This study will test the hypotheses that: 1) improvements in aerobic fitness of older adults will lead to improved performance on a variety of cognitive processes, and especially those processes that are supported by frontal regions of the brain; 2) improvements in cognitive processes due to enhanced aerobic fitness will be visible on fMRI scans, and will be similar to those of young adults; 3) improvements in aerobic fitness, over the course of a 1 year intervention, will result in increases in gray and white matter volume.

One hundred forty sedentary older adults will be recruited for this study. Participants will be randomized to an aerobic exercise intervention group, or to a stretching and toning control group. Aerobic exercise sessions will be conducted three times a week for one year, beginning at a light to moderate intensity level over the first two months and progressing to a moderate to high level for the remainder of the year. The control group will meet on the same basis as the intervention group, and will participate in an organized program of stretching, limbering, and toning for the whole body that is specially designed for individuals 60 years of age and older.

During this time, participants will exercise, keep a daily exercise log detailing distance walked (routes will be measured and mapped for participants), time spent in aerobic activity, degree of intensity (rating of perceived exertion), general level of affect during exercise, resting and exercise heart rates. Participants will participate in the MRI/fMRI, physiological (cardiorespiratory) and psychosocial testing prior to the beginning of the fitness training intervention, following 6 months of fitness training, and at the conclusion of the 1 year of fitness training.

  Eligibility

Ages Eligible for Study:   60 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy adults over 60

Criteria

Inclusion Criteria:

  • 60 to 75 years of age (for Sedentary Older Adults)
  • Sedentary Older Adults: no physical activity in last six months; Young Comparison Sample: Moderately active lifestyle
  • Capable of performing exercise
  • Personal physician's examination and consent to participate in testing and exercise or control intervention
  • Successful completion of graded exercise test without evidence of cardiac abnormalities or responses
  • Adequate performance on the Pfeiffer (1979) Mental Status measure - Corrected (near and far) vision 20/40 or better
  • Right-handed
  • Intention to remain in the local area over the study period

Exclusion Criteria:

  • Sedentary Older Adults: self reported physical activity on regular basis (2 times or more per week) in last six months; Young Comparison Sample: sedentary or highly active/athletic lifestyle
  • Any physical disability that prohibits mobility (walking), stretching etc.
  • Depression score on GDS indicative of clinical depression
  • Presence of any implanted devices such as cardiac pacemakers or autodefibrillators; neural pacemakers, aneurysm clips in the CNS; cochlear implants; metallic bodies in the eye or CNS; any form of wires or metal devices that concentrate radiofrequency fields
  • Left-handed
  • Individuals with chronic inflammation (e.g. severe arthritis, psoriasis, inflammatory bowel disease, asthma, polyneuropathies, Lupus)
  • Intent to move or take an extended vacation (i.e. longer than 1 month during the study period)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00438347

Contacts
Contact: Art Kramer, PhD 217-244-1933 a-kramer@illinois.edu

Locations
United States, Illinois
Beckman Institute, University of Illinois Recruiting
Champaign, Illinois, United States, 61801
Principal Investigator: Art Kramer, PhD         
Sub-Investigator: Neal Cohen, PhD         
Sub-Investigator: Stanley Colcombe, PhD         
Sub-Investigator: Edward McAuley, PhD         
Sub-Investigator: Bradley Sutton, PhD         
Sub-Investigator: Jeffery Woods, PhD         
Sponsors and Collaborators
University of Illinois at Urbana-Champaign
Investigators
Principal Investigator: Art Kramer, PhD Beckman Institute, University of Illinois
  More Information

Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Arthur Kramer, Director, Beckman Institute, University of Illinois at Urbana-Champaign
ClinicalTrials.gov Identifier: NCT00438347     History of Changes
Other Study ID Numbers: IA0102, 5R37AG025667-02
Study First Received: February 21, 2007
Last Updated: March 29, 2014
Health Authority: United States: Federal Government

Keywords provided by University of Illinois at Urbana-Champaign:
Mild Cognitive Impairment
cognition disorders
brain health
psychological aspect of aging
exercise
physical fitness

ClinicalTrials.gov processed this record on September 18, 2014