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A Study to Assess the Safety & Interaction Between GW679769, Dexamethasone, & Ondansetron When Taken by Healthy Adults

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
GlaxoSmithKline
ClinicalTrials.gov Identifier:
NCT00437229
First received: February 16, 2007
Last updated: May 31, 2012
Last verified: February 2011
History of Changes
  Purpose

GW679769 may affect liver enzymes that metabolize dexamethasone and ondansetron. This study is designed to test the safety and the extent of the GW679769 affect on dexamethasone and ondansetron levels in humans.


Condition Intervention Phase
Healthy Subjects
Nausea and Vomiting, Chemotherapy-Induced
 Drug: GW679769 Oral Tablets
Drug: dexamethasone oral tablets & intravenous
Drug: ondansetron oral tablets & intravenous
 Phase 1

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Pharmacokinetics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: An Open-Label, Phase I Study to Assess the Pharmacokinetic Interaction Between Repeat Doses of Oral Casopitant [GW679769] and Intravenous and Oral Doses of Dexamethasone and Intravenous and Oral Doses of Ondansetron When Administered in Healthy Adult Subjects

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by GlaxoSmithKline:

Primary Outcome Measures:
  • Part A: Period 1 & 2: Plasma levels of casopitant, dexamethasone, & ondansetron will be checked on Day 1, 2 and/or 3. Part B: Period 1, 2 & 3: Plasma levels of casopitant, dexamethasone, & ondansetron will be checked on Day 1, 2 and/or 3. [ Time Frame: checked on Day 1, 2 and/or 3 ]

Secondary Outcome Measures:
  • Safety is evaluated by: Clinical Lab Tests done [ Time Frame: at Screening, Day -1 & Followup. ]
  • Vitals Signs taken & Adverse Events monitored [ Time Frame: at each visit starting at Day -1. ]
  • 12 lead ECGs & Serum Pepsinogen level tests [ Time Frame: at Screening & Followup. ]

Enrollment: 37
Study Start Date: February 2007
Study Completion Date: May 2007
Intervention Details:
    Drug: GW679769 Oral Tablets Drug: dexamethasone oral tablets & intravenous Drug: ondansetron oral tablets & intravenous
    Other Names:
    • GW679769 Oral Tablets
    • dexamethasone oral tablets & intravenous
    • ondansetron oral tablets & intravenous
  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy adult males or females
  • Age: 18 to 55 years, inclusive
  • A female subject who is non-childbearing potential or using acceptable contraceptive methods.
  • Adequate organ systems function
  • Able to swallow and retain oral medication
  • Able to understand and comply with protocol requirements and instruction and is likely to complete the study.

Exclusion Criteria:

  • Cannot participation if subject has a clinically relevant abnormality, medical condition, or circumstance that makes them unsuitable for the study per the study doctor.
  • History of drug or other allergy which, in the opinion of the Investigator, contraindicates participation.
  • Use of an investigation drug within 28 days or 5 half-lives.
  • Blood donation in excess of 500mL within 56 days prior to dosing or intends to donate within 30 days of the post-treatment follow-up visit.
  • Presence of or suspected iron deficiency
  • Positive stool for occult blood
  • Female subject who is lactating
  • Positive urine drug screen
  • Positive for HIV antibody, hepatitis C antibody or hepatitis B surface antigen
  • Use of tobacco-containing products within the past 12 months prior to screening
  • History of drug or alcohol abuse or dependence within 6 months of screening
  • History or presence of uncontrolled emesis
  • Positive purified protein derivative (PPD) skin test for tuberculosis
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00437229

Locations
United States, New York
GSK Investigational Site
Buffalo, New York, United States, 14202
Sponsors and Collaborators
GlaxoSmithKline
Investigators
Study Director: GSK Clinical Trials GlaxoSmithKline
  More Information

Publications:

Responsible Party: GlaxoSmithKline
ClinicalTrials.gov Identifier: NCT00437229     History of Changes
Other Study ID Numbers: NKV100787
Study First Received: February 16, 2007
Last Updated: May 31, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by GlaxoSmithKline:
GW679769,
Casopitant,
Dexamethasone,
Healthy Human Volunteer
Ondansetron,

Additional relevant MeSH terms:
Vomiting
Signs and Symptoms, Digestive
Signs and Symptoms
Dexamethasone acetate
Dexamethasone
Ondansetron
Dexamethasone 21-phosphate
BB 1101
Anti-Inflammatory Agents
Therapeutic Uses
Pharmacologic Actions
Antiemetics
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
 Central Nervous System Agents
Gastrointestinal Agents
Glucocorticoids
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Antineoplastic Agents, Hormonal
Antineoplastic Agents
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antipruritics
Dermatologic Agents
Serotonin Antagonists
Serotonin Agents
Neurotransmitter Agents

ClinicalTrials.gov processed this record on May 19, 2013