Bortezomib in Treating Patients With Advanced Myeloproliferative Disorders

This study has been completed.
Sponsor:
Collaborator:
Information provided by:
Mayo Clinic
ClinicalTrials.gov Identifier:
NCT00437086
First received: February 15, 2007
Last updated: March 29, 2011
Last verified: March 2011
  Purpose

RATIONALE: Bortezomib may stop the growth of abnormal cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the abnormal cells.

PURPOSE: This clinical trial is studying the side effects and how well bortezomib works in treating patients with advanced myeloproliferative disorders.


Condition Intervention
Chronic Myeloproliferative Disorders
Leukemia
Drug: PS-341

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Prospective Open-Label Pilot Trial of PS-341 (Bortezomib; VELCADE) for the Therapy of Symptomatic Advanced Myeloproliferative Disorders

Resource links provided by NLM:


Further study details as provided by Mayo Clinic:

Primary Outcome Measures:
  • Number and severity of toxicities as assessed by NCI CTCAE v3.0 [ Time Frame: 40 weeks ] [ Designated as safety issue: Yes ]
  • Proportion of patients who show treatment success, as defined by anemia, spleen, bone marrow, or constitutional symptoms' response (complete, partial, major, or minor response) [ Time Frame: 40 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Effects of treatment, in terms of changes in bone marrow cellularity, tryptase-positive mast cells, reticulin fibrosis, osteosclerosis, and angiogenesis, in responding patients [ Time Frame: 40 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: September 2005
Study Completion Date: November 2008
Primary Completion Date: November 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: PS-341
Designed to assess the toxicity and pilot response of PS-341 in patients with advanced myeloproliferative diseases.
Drug: PS-341
1.6 mg/m2 by IV; 4 out of 5 weeks
Other Name: Bortezomib, Velcade, MLN-341, LDP-341

Detailed Description:

OBJECTIVES:

Primary

  • Determine the efficacy of bortezomib in patients with symptomatic advanced myeloproliferative disorders (i.e., myelofibrosis with myeloid metaplasia, chronic myelomonocytic leukemia, or FIP1LI-PDGFRA-negative mast cell disease).
  • Determine the safety of this drug when administered on a modified schedule in these patients.

Secondary

  • Determine the effect of this drug on bone marrow cellularity, tryptase-positive mast cells, reticulin fibrosis, osteosclerosis, and angiogenesis in responding patients

OUTLINE: This is a prospective, open-label, pilot, multicenter study. Patients are stratified according to disease (systemic mast cell disease vs chronic myelomonocytic leukemia vs myelofibrosis with myeloid metaplasia).

Patients receive bortezomib IV weekly for 4 weeks. Treatment repeats every 5 weeks for up to 2 courses in the absence of disease progression or unacceptable toxicity. Patients achieving a response (complete remission, partial remission, or minimal remission) after 2 courses may receive an additional 6 courses of therapy. Patients who achieve stable disease with acceptable toxicities after 2 courses receive bortezomib IV at a higher dose twice weekly for 2 weeks. Treatment with a higher dose of bortezomib repeats every 3 weeks for up to 6 courses.

Patients who are responders undergo bone marrow aspirate or biopsy and peripheral blood collection for evaluation of bone marrow cellularity, tryptase-positive mast cells, reticulin fibrosis, osteosclerosis, and angiogenesis by fluorescent in situ hybridization (FISH), immunohistochemistry, and other immunological laboratory methods.

After completion of study therapy, patients are followed periodically for up to 3 years.

PROJECTED ACCRUAL: A total of 30 patients will be accrued for this study.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed advanced myeloproliferative disorder, including 1 of the following subtypes:

    • Myelofibrosis with myeloid metaplasia defined by the following criteria:

      • Evaluable or symptomatic disease as evidenced by ≥ 1 of the following:

        • Anemia, defined as hemoglobin < 10 g/dL OR erythrocyte-transfusion dependence, defined as requiring 1 transfusion within the past 8 weeks
        • Symptomatic palpable splenomegaly (palpable hepatomegaly is acceptable if previously splenectomized) requiring treatment* NOTE: *Subjective but painful enough to mandate intervention
    • Chronic myelomonocytic leukemia (CMML) defined by the following criteria:

      • Absence of an imatinib mesylate-sensitive molecular abnormality for CMML (i.e., t[5;12], t[5;10], t[1;5], and t[5;7]) confirmed by fluorescent in situ hybridization (FISH) or standard cytogenetic bone marrow analysis within the past 18 months
      • Symptomatic disease as evidenced by ≥ 1 of the following:

        • Anemia, defined as hemoglobin < 10 g/dL OR erythrocyte-transfusion dependence, defined as requiring 1 transfusion within the past 8 weeks
        • Palpable splenomegaly (palpable hepatomegaly is acceptable if previously splenectomized) requiring treatment* NOTE: *Subjective but painful enough to mandate intervention
        • Leukocytosis associated with ascites, serositis, pleural effusions, vasculitis, or other overt manifestation
    • Systemic mast cell disease defined by the following criteria:

      • Absence of the FIP1LI-PDGFRA mutation as confirmed by FISH
      • Evaluable and symptomatic disease requiring therapy, as evidenced by involvement with organs other than skin (i.e., heart, bowel, peripheral blood, liver/spleen, or marrow)
      • Debilitating mast cell mediator symptoms not responsive to standard therapy such as antihistamines
  • Absence of t(9;22) translocation as confirmed by FISH or standard cytogenetic peripheral blood or marrow analysis at any prior time point

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-2
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • Not incarcerated in a municipal, county, state, or federal prison
  • Absolute neutrophil count ≥ 1,000/mm³
  • Platelet count ≥ 75,000/mm³
  • Creatinine ≤ 2.0 mg/dL
  • Total or direct bilirubin ≤ 2.0 mg/dL
  • AST and ALT ≤ 3 times upper limit of normal (unless clinically attributed to hepatic extramedullary hematopoiesis)
  • No baseline peripheral or autonomic neuropathy ≥ grade 2
  • No other condition or laboratory abnormality that would place the patient at unacceptable risk or confound the ability to interpret study data
  • No hypersensitivity to boron, mannitol, or bortezomib
  • No myocardial infarction within the past 6 months
  • No New York Hospital Association class III-IV heart failure
  • No uncontrolled angina
  • No severe uncontrolled ventricular arrhythmia
  • No evidence of acute ischemia or active conduction system abnormality by ECG

    • ECG screening abnormalities must be documented as not medically relevant
  • No other serious medical or psychiatric illness that would preclude study participation

PRIOR CONCURRENT THERAPY:

  • At least 14 days since prior chemotherapy (e.g., interferon alfa, anagrelide, or other myelosuppressive agent) or any other experimental therapy
  • At least 14 days since prior growth factors
  • At least 14 days since prior systemic use of corticosteroids
  • More than 14 days since prior investigational drugs
  • Concurrent hydroxyurea allowed for ≤ 14 days during study therapy if clinically indicated for extreme leukocytosis control
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00437086

Locations
United States, Florida
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
United States, Texas
M. D. Anderson Cancer Center at University of Texas
Houston, Texas, United States, 77030-4009
Sponsors and Collaborators
Mayo Clinic
Investigators
Study Chair: Ruben A. Mesa, M.D. Mayo Clinic
Principal Investigator: Candido E. Rivera, M.D. Mayo Clinic
  More Information

Additional Information:
No publications provided

Responsible Party: Ruben Anthony Mesa, M.D., Mayo Clinic Cancer Center
ClinicalTrials.gov Identifier: NCT00437086     History of Changes
Other Study ID Numbers: CDR0000529906, P30CA015083, MC0486, 695-05, VEL-04-107
Study First Received: February 15, 2007
Last Updated: March 29, 2011
Health Authority: United States: Food and Drug Administration

Keywords provided by Mayo Clinic:
chronic myelomonocytic leukemia
primary myelofibrosis

Additional relevant MeSH terms:
Leukemia
Myeloproliferative Disorders
Neoplasms by Histologic Type
Neoplasms
Bone Marrow Diseases
Hematologic Diseases
Bortezomib
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on July 29, 2014