Frequency of ICAM-1 Polymorphisms in Obese Subjects

This study has been completed.
Sponsor:
Information provided by:
Istituto Auxologico Italiano
ClinicalTrials.gov Identifier:
NCT00436488
First received: February 16, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted
  Purpose

The genetic contribution to the development of obesity is now well recognized. However obesity is a polygenic disease and thus many genes are likely to be involved. This study aims to investigate the possible association between specific variants of the gene coding for the Intercellular Adhesion Molecule-1 (ICAM-1)and the development of severe obesity in an Italian population


Condition
Obesity

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Official Title: Study of the Association Between ICAM-1 Polymorphisms and Severe Obesity

Resource links provided by NLM:


Further study details as provided by Istituto Auxologico Italiano:

Estimated Enrollment: 200
Study Start Date: January 2005
Estimated Study Completion Date: July 2006
Detailed Description:

Severely obese subjects referred to our institution will be evaluated. For the aim of the study, a venous blood sample will be obtained from these subjects and from a group of normal weight volunteers. Genomic DNA will be extracted from the blood samples and analysed by standard molecular biology techniques.The allelic and genotype frequencies of the two ICAM-1 variants will be calculated in the obese and control groups. The statistical significance of possible differences will be determined

  Eligibility

Ages Eligible for Study:   18 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Obesity

Exclusion Criteria:

  • Associated inflammatory diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00436488

Sponsors and Collaborators
Istituto Auxologico Italiano
Investigators
Principal Investigator: Anna Maria Di Blasio, MD Istituto Auxologico Italiano
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00436488     History of Changes
Other Study ID Numbers: 12C501
Study First Received: February 16, 2007
Last Updated: February 16, 2007
Health Authority: Italy: Ethics Committee

Keywords provided by Istituto Auxologico Italiano:
ICAM-1
Obesity
Gene variants

Additional relevant MeSH terms:
Obesity
Overnutrition
Nutrition Disorders
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on July 22, 2014