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| Sponsor: | University of Louisville |
|---|---|
| Collaborator: |
National Institute on Aging (NIA) |
| Information provided by (Responsible Party): | Irene Litvan, University of Louisville |
| ClinicalTrials.gov Identifier: | NCT00431301 |
Purpose
Progressive supranuclear palsy (PSP) is the most common atypical parkinsonian movement disorder. This study will determine the role of specific genetic, occupational and environmental components in the development of PSP by evaluating patients with this disorder and age and gender matched controls.
| Condition |
|---|
|
Progressive Supranuclear Palsy |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Genetic and Environmental Risk Factors for PSP |
DNA will be used for genotyping specific genes of interest related to the disease.
| Estimated Enrollment: | 1500 |
| Study Start Date: | August 2006 |
| Estimated Study Completion Date: | August 2012 |
This proposal will determine: (1) if there is an association between PSP and specific genes of interest; (2) if there is an association between PSP and occupational and/or environmental chemical exposures functionally or structurally similar to known parkinsonian toxicants; and (3) if hypertension or traumatic brain injury prior to symptom-onset is associated with PSP. To disentangle the complex etiology of PSP, this case-control multicenter study involves 500 PSP cases, 500 age/gender matched primary controls, and 500 secondary controls for genetic confirmation. Understanding the etiology of PSP may also help explain the causes of other related diseases such as Alzheimer's disease. This multidisciplinary team of movement disorder specialists, epidemiologists, geneticists, biostatisticians, industrial hygienist and toxicologist is well suited to unravel the etiology of PSP.
Eligibility| Ages Eligible for Study: | 40 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Patients with clinically diagnosed Progressive Supranuclear Palsy and healthy controls
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Christopher Cunningham, Ph.D. | 1-866-PSP-0448 | |
| Contact: Casey Shepherd, M.P.H. | 1-866-PSP-0448 |
| United States, Alabama | |
| University of Alabama, Birmingham | Recruiting |
| Birmingham, Alabama, United States, 35233 | |
| Contact: Jenna Smith 205-975-0338 | |
| Principal Investigator: David Standaert, M.D., Ph.D. | |
| United States, California | |
| UCLA | Recruiting |
| Los Angeles, California, United States, 90095-1759 | |
| Contact: Arik Johnson 310-825-4989 | |
| Principal Investigator: Yvette Bordelon, M.D. | |
| United States, Colorado | |
| University of Colorado | Recruiting |
| Aurora, Colorado, United States, 80045 | |
| Contact: Carol Hennessey 720-848-5334 | |
| Principal Investigator: Benzi Kluger, MD | |
| United States, Georgia | |
| Emory College of Medicine | Recruiting |
| Atlanta, Georgia, United States, 30322 | |
| Contact: Mary Louise Weeks 404-728-6859 | |
| Principal Investigator: Jorge Juncos, M.D. | |
| United States, Illinois | |
| Rush University | Recruiting |
| Chicago, Illinois, United States, 60611 | |
| Contact: Jean A Jaglin, RN 312-563-2900 | |
| Principal Investigator: Deborah Hall, MD, PhD | |
| United States, Kansas | |
| University of Kansas | Recruiting |
| Kansas City, Kansas, United States, 66160 | |
| Contact: Janice Broyles-Gorman 913-588-0683 | |
| Principal Investigator: Richard Dubinsky, MD, MPH | |
| United States, Kentucky | |
| University of Louisville | Recruiting |
| Louisville, Kentucky, United States, 40202 | |
| Contact: Chris Cunningham, Ph.D. 866-777-0448 | |
| Contact: Casey Shepherd, M.P.H. 502-852-3655 | |
| Principal Investigator: Irene Litvan, M.D. | |
| United States, Maryland | |
| University of Maryland | Recruiting |
| Baltimore, Maryland, United States, 21201 | |
| Contact: Katie Holmes 410-328-4892 | |
| Principal Investigator: Stephen Reich, M.D. | |
| United States, Ohio | |
| Case Western University | Recruiting |
| Cleveland, Ohio, United States, 44106 | |
| Contact: David Korosec 216-844-1800 | |
| Principal Investigator: David Riley, M.D. | |
| Canada, Ontario | |
| University of Toronto | Recruiting |
| Toronto, Ontario, Canada, M5T 2S8 | |
| Contact: Raquel Subido 416-603-5800 ext 5343 | |
| Principal Investigator: Connie Marras, MD, PhD | |
| Principal Investigator: | Irene Litvan, M.D. | University of Louisville |
More Information
| Responsible Party: | Irene Litvan, Principle Investigator, University of Louisville |
| ClinicalTrials.gov Identifier: | NCT00431301 History of Changes |
| Other Study ID Numbers: | 1 R01 AG024040-01A2, 1 R01 AG024040-01A2 |
| Study First Received: | February 1, 2007 |
| Last Updated: | December 8, 2011 |
| Health Authority: | United States: Institutional Review Board |
|
Progressive Supranuclear Palsy Epidemiology Case-Control Genetic Environmental Neurodegenerative Disease |
Movement Disorders Atypical Parkinsonism Parkinson Plus Steele-Richardson-Olszewski PSP |
|
Supranuclear Palsy, Progressive Paralysis Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Nervous System Diseases Movement Disorders Ophthalmoplegia |
Ocular Motility Disorders Cranial Nerve Diseases Tauopathies Neurodegenerative Diseases Neurologic Manifestations Eye Diseases Signs and Symptoms |
