Renal Transporters After Renal Transplantation

The recruitment status of this study is unknown because the information has not been verified recently.

Verified February 2007 by University Hospital Muenster.
Recruitment status was Not yet recruiting

Sponsor:

Information provided by:

University Hospital Muenster

ClinicalTrials.gov Identifier:

NCT00427024

First received: January 25, 2007

Last updated: February 5, 2007

Last verified: February 2007

History of Changes

Purpose

Previous studies in animals revealed, that the activity of certain transporters along the nephron is changed with acute rejection after renal transplantation. We intend to investigate underlying mechanisms occurring in man in renal biopsy specimens obtained from patients because of acute rejection of the transplant or chronic transplant nephropathy.

Condition
Kidney Transplantation Host vs Graft Reaction

Study Type:	Observational
Study Design:	Observational Model: Defined Population Primary Purpose: Screening Time Perspective: Cross-Sectional Time Perspective: Prospective
Official Title:	Study of Renal Transporters and Their Regulators After Renal Transplantation

Resource links provided by NLM:

MedlinePlus related topics: Kidney Transplantation

U.S. FDA Resources

Further study details as provided by University Hospital Muenster:

Estimated Enrollment:	200
Study Start Date:	February 2007
Estimated Study Completion Date:	February 2009

Show Detailed Description

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

individuals transplanted with a donor kidney
individuals with acute transplant rejection

Exclusion Criteria:

pregnancy
malignant disease
HIV infection

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00427024

Contacts

Contact: Gert Gabriëls, PD Dr. med.	0049-251-83-47676	gabrie@uni-muenster.de
Contact: Hermann Pavenstädt, Prof. Dr. med.	0049-251-83-47516	Hermann.Pavenstaedt@ukmuenster.de

Locations

Germany
University Hospital Münster	Not yet recruiting
Münster, Germany, 48149
Contact: Gert Gabriëls, PD Dr. med. 0049-251-83-47676 gabrie@uni-muenster.de
Contact: Hermann Pavenstädt, Prof. Dr. med. 0049-83-251-47516 Hermann.Pavenstaedt@ukmuenster.de
Principal Investigator: Gert Gabriëls, PD Dr. med.

Sponsors and Collaborators

University Hospital Muenster

Investigators

Study Chair:

Gert Gabriëls, PD Dr. med.

University Hospital Münster

More Information

Publications:

Velic A, Gabriels G, Hirsch JR, Schroter R, Edemir B, Paasche S, Schlatter E. Acute rejection after rat renal transplantation leads to downregulation of NA+ and water channels in the collecting duct. Am J Transplant. 2005 Jun;5(6):1276-85.

Velic A, Hirsch JR, Bartel J, Thomas R, Schroter R, Stegemann H, Edemir B, August C, Schlatter E, Gabriels G. Renal transplantation modulates expression and function of receptors and transporters of rat proximal tubules. J Am Soc Nephrol. 2004 Apr;15(4):967-77.

ClinicalTrials.gov Identifier:	NCT00427024 History of Changes
Other Study ID Numbers:	NTX + Transport
Study First Received:	January 25, 2007
Last Updated:	February 5, 2007
Health Authority:	Germany: Ethics Commission

Keywords provided by University Hospital Muenster:

renal transplantation
acute rejection
transport
transporter
acute rejection after renal transplantation

ClinicalTrials.gov processed this record on June 17, 2013

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