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Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System

This study has been completed.
Sponsor:
Information provided by:
University of Aarhus
ClinicalTrials.gov Identifier:
NCT00424957
First received: January 19, 2007
Last updated: February 4, 2009
Last verified: February 2009
History of Changes
  Purpose

The purpose of the current study is to look into the pathogenesis of a severe medical condition causing acute episodes on the central nervous system as seen in majority of patients with liver cirrhosis.


Condition
Cirrhosis
Hepatic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Brain Energy Metabolism in Patients With Acute Hepatic Encephalopathy Measured With PET

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University of Aarhus:

Estimated Enrollment: 18
Study Start Date: November 2006
Study Completion Date: October 2008
Primary Completion Date: April 2007 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   45 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy, 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy, 6 healthy subjects age and sex matched

Criteria

Inclusion Criteria:

  • 6 patients with liver cirrhosis with an acute episode of hepatic encephalopathy,
  • 6 patients with liver cirrhosis without an acute episode of hepatic encephalopathy,
  • 6 healthy subjects age and sex matched

Exclusion Criteria:

  • Neurological and/or psychiatric condition,
  • Non-treated diabetes,
  • Pregnancy/breast-feeding
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00424957

Locations
Denmark
PET Centre, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Investigators
Study Chair: Susanne Keiding, MD PET Centre and Medical department V, Aarhus Sygehus, Aarhus University Hospital
  More Information

Additional Information:
Liver research group at PET Centre, Aarhus University Hospital  This link exits the ClinicalTrials.gov site

Publications:

Responsible Party: Peter Iversen, PET Center, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT00424957     History of Changes
Other Study ID Numbers: 20060120
Study First Received: January 19, 2007
Last Updated: February 4, 2009
Health Authority: Denmark: Ethics Committee
Denmark: The Danish National Committee on Biomedical Research Ethics
Denmark: Danish Dataprotection Agency

Keywords provided by University of Aarhus:
Ammonia
Astrocytes
Citric acid cycle
Alpha ketoglutarate dehydrogenase

Additional relevant MeSH terms:
Hepatic Encephalopathy
Liver Cirrhosis
Fibrosis
Brain Damage, Chronic
Delirium
Encephalitis
Neurotoxicity Syndromes
Liver Failure
Hepatic Insufficiency
Liver Diseases
Digestive System Diseases
Brain Diseases, Metabolic
Brain Diseases
Central Nervous System Diseases
 Nervous System Diseases
Metabolic Diseases
Pathologic Processes
Confusion
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders
Central Nervous System Viral Diseases
Virus Diseases
Central Nervous System Infections
Poisoning
Substance-Related Disorders

ClinicalTrials.gov processed this record on June 18, 2013