Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

This study has been completed.
Sponsor:
Information provided by:
Klinikum Ludwigshafen
ClinicalTrials.gov Identifier:
NCT00416299
First received: December 26, 2006
Last updated: January 29, 2009
Last verified: January 2009
  Purpose

To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.


Condition
Cardiac Surgery

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery

Resource links provided by NLM:


Further study details as provided by Klinikum Ludwigshafen:

Enrollment: 100
Study Start Date: May 2007
Study Completion Date: August 2007
Detailed Description:

Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.

  Eligibility

Ages Eligible for Study:   75 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients aged 75 years or older undergoing elective cardiac surgery with CPB

Exclusion Criteria:

  • positive cardiac troponin T test within the week before surgery
  • patients undergoing emergent procedures
  • patients with preoperative mechanical cardiac support
  • patients undergoing hemodialysis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00416299

Locations
Germany
Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen
Ludwigshafen, Germany, 67063
Sponsors and Collaborators
Klinikum Ludwigshafen
Investigators
Principal Investigator: Stefan W. Suttner, MD Klinikum Ludwigshafen
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00416299     History of Changes
Other Study ID Numbers: KliLuNTproBNP
Study First Received: December 26, 2006
Last Updated: January 29, 2009
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by Klinikum Ludwigshafen:
Cardiac biomarker
cardiac surgery
elderly
postoperative complications
Patients aged 75 years or older undergoing cardiac surgery

ClinicalTrials.gov processed this record on September 16, 2014