Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery
To evaluate the use of new cardiac biomarker for the prediction of in-hospital cardiovascular complications in elderly patients undergoing elective cardiac surgery.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Observational Cohort Study on the Prognostic Value of New Cardiac Biomarkers in Elderly Patients Undergoing Cardiac Surgery|
|Study Start Date:||May 2007|
|Study Completion Date:||August 2007|
Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP, cardiac troponin T (cTnT), pregnancy-associated plasma protein A (PAPP-A), ischemia-modified albumin (IMA), myeloperoxidase (MPO), metalloproteinase (MMP) soluble CD 40 ligand (sCD40L), and inflammatory cytokine levels will be measured in 100 elderly patients undergoing elective cardiac surgery with cardiopulmonary bypass before induction of anesthesia and 12 h, 24 h, and 48 h after surgery. Optimum discriminators for prediction of postoperative cardiovascular complications wil be determined by the use of receiver operating characteristics (ROC) curves analyses.
|Department of Anesthesiology and Intensive Care Medicine Klinikum Ludwigshafen|
|Ludwigshafen, Germany, 67063|
|Principal Investigator:||Stefan W. Suttner, MD||Klinikum Ludwigshafen|