Non-Invasive Biomarkers in Cystic Fibrosis
Background Chronic airway inflammation is present in cystic fibrosis. Non-invasive inflammometry may be useful in disease management.
Objective We studied 1) the ability of fractional exhaled nitric oxide and inflammatory markers (acidity, nitrite, nitrate, hydrogen peroxide, 8-isoprostane, interferon-γ, tumor necrosis factor-α, interleukin-2,-4,-5,-10) in exhaled breath condensate, to discriminate between cystic fibrosis and control children, and, 2) the relationship of biomarkers with control and severity of cystic fibrosis.
Methods In 98 children (48 cystic fibrosis / 50 controls), condensate was collected using a glass condenser. Exhaled nitric oxide was measured using the NIOX®.
|Study Design:||Allocation: Random Sample
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
|Official Title:||Biomarkers in Exhaled Breath Indicate Presence, Control and Severity of Cystic Fibrosis|
|University Hospital Maastricht|
|Maastricht, Netherlands, 6202AZ|
|St Radboud Childrens Hospital|
|Máxima Medical Centre|
|Principal Investigator:||Charlotte M Robroeks, M||Maastricht University Medical Center|
|Study Director:||Edward Dompeling, MD, PhD||Maastricht University Medical Center|
|Study Director:||Quirijn Jöbsis, MD, PhD||Maastricht University Medical Center|