Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction
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Purpose
The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.
It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.
| Condition |
|---|
|
Myocardial Infarction |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Protective Effect of Coronary Collaterals on Infarct Size in Patients With Acute Myocardial Infarction |
| Estimated Enrollment: | 105 |
| Study Start Date: | July 2010 |
The hypothesis of the current proposal is that collateral flow is an important determinant of myocardial protection during an ischemic event. Increased collateral flow for any given area at risk will decrease the myocardial damage caused by the occlusion of the infarct related epicardial artery.
It is further hypothesized that myocardial salvage provided by collateral flow will decrease infarct size and this in turn will decrease LV dilatation post-myocardial infarction.
The two primary endpoints are infarct size as assessed by increase of biochemical cardiac markers and coronary collateral perfusion index (CPI) as obtained by transthoracic MCE.
Extent of LV remodelling, i.e., LV dilatation as assessed by serial assessment of LV dimension by LV angiogram and/or echocardiography, respectively.
Eligibility| Ages Eligible for Study: | 18 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Patients with acute myocardial infarction undergoing primary PCI as reperfusion therapy of a totally occluded coronary artery.
Inclusion Criteria:
- Patients with acute myocardial infarction with electrocardiographic criterion and/or typical history of angina pectoris and planned revascularisation according to the acute myocardial infarction disease management guidelines of the University Hospital Bern. Including both, patients undergoing primary PCI and patients referred for rescue PCI after failed thrombolytic therapy
- Patients > 18 years old of either sex
- Patients who have given informed consent to the study
Exclusion Criteria:
- Patients unable to give informed consent e.g. because of mechanical ventilation
- Patients with cardiogenic shock
- Patients with myocardial infarction secondary to occlusion of a recently revascularized vessel (subacute stent thrombosis)
- Patients with severe arrhythmias
- Patients whose door-to-balloon time exceeds 120 minutes
- Pregnancy
Contacts and Locations| Switzerland | |
| University Hospital Inselspital | |
| Bern, Switzerland, 3010 | |
| Principal Investigator: | Christian Seiler, Prof. | University Hospital Bern, Switzerland |
More Information
No publications provided
| Responsible Party: | Christian Seiler, MD, Professor and Co-Chairman of Cardiology, Department of Cardiology, University Hospital, CH-3010 Bern, Switzerland |
| ClinicalTrials.gov Identifier: | NCT00412672 History of Changes |
| Other Study ID Numbers: | 37/01 |
| Study First Received: | December 15, 2006 |
| Last Updated: | October 22, 2010 |
| Health Authority: | Switzerland: Swissmedic |
Keywords provided by University Hospital Inselspital, Berne:
|
Myocardial infarction contrast echocardiography collateral circulation |
Additional relevant MeSH terms:
|
Infarction Myocardial Infarction Ischemia Pathologic Processes Necrosis |
Myocardial Ischemia Heart Diseases Cardiovascular Diseases Vascular Diseases |
ClinicalTrials.gov processed this record on May 16, 2013