Inflammatory Markers in Exhaled Breath (Condensate) in Childhood Asthma
Exhaled nitric oxide and inflammatory biomarkers in exhaled breath condensate may be useful to diagnose and monitor childhood asthma. Their ability to indicate an asthma diagnosis, and to assess asthma severity and control, is largely unknown.
To study 1) the ability of exhaled nitric oxide and inflammatory markers in exhaled breath condensate (nitrite, nitrate, hydrogen peroxide, 8-isoprostane, interferon-γ, tumor necrosis factor-α, interleukin-2,-4,-5,-10, acidity) to discriminate between childhood asthma and controls. 2) the ability of these biomarkers to indicate asthma severity and control.
114 Children were included: 64 asthmatics (10.7±3.0 years, 67.2% atopic) and 50 controls (10.0±0.4 years). Condensate was collected using a glass condenser
|Study Design:||Allocation: Random Sample
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
|Official Title:||Biomarkers in Exhaled Breath (Condensate) Indicate Presence, Severity and Control of Asthma|
|University Hospital Maastricht|
|Maastricht, Netherlands, 6202AZ|
|Principal Investigator:||Charlotte M Robroeks, MD||Maastricht University Medical Center|
|Study Director:||Edward Dompeling, MD, PhD||Maastricht University Medical Center|
|Study Director:||Quirijn Jöbsis, MD, PhD||Maastricht University Medical Center|