Protocol Chronic Obstructive Pulmonary Disease
Recruitment status was Recruiting
The main objective of the study is to evaluate the predictive factors of the endothelial function to the waning of an acute exacerbation in COPD. It will act to do a multivariate analysis to determine the respective weight of the parameters of the systemic inflammation, of the oxidative stress of the functional respiratory parameters and then functional respiratory parameters.
In exacerbated COPD patients, there is augmentation of hypoxia and the obstructive ventilatory disorders is more important. This is correlated with an increase in CRP and of inflammatory cytokines and oxidative stress. It has been demonstrated that there is an endothelial dysfunction in answer to hypoxia. Since the exacerbated COPD patients are hypoxic in most cases , we suppose they have an endothelial dysfunction during exacerbation. So we think we will find an augmentation of vascular resistances ,shown by a peripheral arterial tone too high. And this , certainly, play a part in physiopathology of the COPD exacerbation.
Chronic Obstructive Pulmonary Disease
Acute Respiratory Failure
|Study Design:||Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:||Predictive Factors of Endothelial Function in Chronic Obstructive Disease Patients at the End of a Acute Exacerbation.|
|Study Start Date:||January 2007|
|Estimated Study Completion Date:||December 2008|
We want to judge the improvement of the endothelial function remotely to the acute exacerbation ( 6 weeks). And then we would like to correlate this improvement with the variations of oxidative stress, the muscular strenght, the respiratory function and the systemic inflammation.
We also would like to find a relation between the new hospitalizations for respiratory exacerbation and the initial value of endothelial function.
|Contact: Jean-Louis JP PEPIN, ProfessorPhD||0033476765516||JPepin@chu-grenoble.fr|
|France : Laboratoire EFCR - Functional Cardio-Respiratory Exploration Laboratory||Recruiting|
|Grenoble, Isere, France, 38043|
|Contact: Jean-Louis JP PEPIN, ProfessorPHD 0033476765516 JPepin@chu-grenoble.fr|
|Sub-Investigator: Jean-Philippe JB BAGUET, ProfessorPHD|
|Sub-Investigator: Patrick PL LEVY, ProfessorPHD|
|Sub-Investigator: Jean-François JT TIMSIT, ProfessorPHD|
|Sub-Investigator: Patrice PF FAURE, PhD|
|Sub-Investigator: Christophe CP PISON, ProfessorPHD|
|Principal Investigator:||Jean-Louis JP Pépin, ProfessorPhD||University Hospital, Grenoble|