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| Sponsor: | National Cancer Institute (NCI) |
|---|---|
| Information provided by: | National Institutes of Health Clinical Center (CC) |
| ClinicalTrials.gov Identifier: | NCT00401037 |
Purpose
RATIONALE: Radiation therapy directed at the central nervous system may change the way blood vessels form in young patients. It may also change brain function, the ability to see and hear, and the patient's quality of life. A study that evaluates young patients for several years after undergoing CNS radiation therapy may help doctors predict a patient's response to treatment and help plan the best treatment.
PURPOSE: This clinical trial is studying the side effects of radiation therapy in young patients with CNS tumors.
| Condition | Intervention |
|---|---|
|
Brain and Central Nervous System Tumors Cognitive/Functional Effects Long-term Effects Secondary to Cancer Therapy in Children Neurotoxicity Psychosocial Effects of Cancer and Its Treatment Radiation Toxicity |
Genetic: polymorphism analysis Genetic: proteomic profiling Other: bioluminescence Other: diagnostic laboratory biomarker analysis Other: immunoenzyme technique Other: mass spectrometry Other: physiologic testing Procedure: cognitive assessment Procedure: dynamic contrast-enhanced magnetic resonance imaging Procedure: magnetic resonance spectroscopic imaging Procedure: management of therapy complications Procedure: psychosocial assessment and care Procedure: quality-of-life assessment |
| Study Type: | Observational |
| Official Title: | An Exploratory Study of Biologic and Pathophysiologic Effects of Radiation Therapy in Pediatric Patients With Central Nervous System Tumors |
| Estimated Enrollment: | 150 |
| Study Start Date: | May 2006 |
Show Detailed Description Eligibility| Ages Eligible for Study: | up to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
Contacts and Locations| United States, Maryland | |
| Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office | Recruiting |
| Bethesda, Maryland, United States, 20892-1182 | |
| Contact: Clinical Trials Office - Warren Grant Magnusen Clinical Center 888-NCI-1937 | |
| Principal Investigator: | Katherine Warren, MD | NCI - Pediatric Oncology Branch |
More Information
| ClinicalTrials.gov Identifier: | NCT00401037 History of Changes |
| Other Study ID Numbers: | 060129, CDR0000500489, NCI-06-C-0219, NCI-P6810 |
| Study First Received: | November 16, 2006 |
| Last Updated: | September 29, 2011 |
| Health Authority: | Unspecified |
|
cognitive/functional effects neurotoxicity radiation toxicity psychosocial effects of cancer and its treatment long-term effects secondary to cancer therapy in children childhood meningioma childhood spinal cord neoplasm childhood central nervous system germ cell tumor childhood high-grade cerebral astrocytoma childhood low-grade cerebral astrocytoma childhood choroid plexus tumor childhood craniopharyngioma childhood infratentorial ependymoma |
childhood supratentorial ependymoma childhood oligodendroglioma childhood atypical teratoid/rhabdoid tumor recurrent childhood brain stem glioma recurrent childhood cerebellar astrocytoma recurrent childhood cerebral astrocytoma newly diagnosed childhood ependymoma recurrent childhood ependymoma recurrent childhood medulloblastoma recurrent childhood supratentorial primitive neuroectodermal tumor recurrent childhood visual pathway and hypothalamic glioma recurrent childhood brain tumor |
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Nervous System Neoplasms Central Nervous System Neoplasms Neurotoxicity Syndromes Radiation Injuries Neoplasms by Site |
Neoplasms Nervous System Diseases Poisoning Substance-Related Disorders Wounds and Injuries |
