Malaria Transmission and Immunity in Highland Kenya

The recruitment status of this study is unknown because the information has not been verified recently.
Verified October 2007 by National Institute of Allergy and Infectious Diseases (NIAID).
Recruitment status was  Recruiting
Sponsor:
Information provided by:
National Institute of Allergy and Infectious Diseases (NIAID)
ClinicalTrials.gov Identifier:
NCT00393757
First received: October 26, 2006
Last updated: August 26, 2010
Last verified: October 2007
  Purpose

The purpose of this study is to see why malaria epidemics occur in highland areas in Kenya. A better understanding of factors contributing to malaria may be necessary for malaria vaccine planning. These factors include interactions between age, where malaria is passed from mosquitoes to people, immune system (how the body fights infection) responses and other factors that contribute to malaria in epidemic-prone areas. About 6400 people from the villages of Kapsisiywa and Kipsamoite will participate. Study procedures will include in home surveys, which will involve a census and an interview by researchers. Blood samples and smears will be collected from some volunteers in both communities to understand how the body protects itself from malaria and to check for malaria parasites. Twice each month, random houses will be selected from 3 places in the village to measure the number of mosquitoes in the home. Participants may be involved in the study for up to 4 years.


Condition
Plasmodium Falciparum Malaria

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Malaria Transmission and Immunity in Highland Kenya

Resource links provided by NLM:


Further study details as provided by National Institute of Allergy and Infectious Diseases (NIAID):

Estimated Enrollment: 6400
Study Start Date: October 2006
Estimated Study Completion Date: January 2010
Detailed Description:

The purpose of this study is to see why malaria epidemics occur in highland areas in Kenya. A better understanding of factors contributing to malaria may be necessary for malaria vaccine planning. These factors include interactions between age, where malaria is passed from mosquitoes to people, immune system (how the body fights infection) responses and other factors that contribute to malaria in epidemic-prone areas. About 6400 people from the villages of Kapsisiywa and Kipsamoite will participate. Study procedures will include in home surveys, which will involve a census and an interview by researchers. Blood samples and smears will be collected from some volunteers in both communities to understand how the body protects itself from malaria and to check for malaria parasites. Twice each month, random houses will be selected from 3 places in the village to measure the number of mosquitoes in the home. Participants may be involved in the study for up to 4 years.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Active surveillance of clinical malaria -Individuals of any age who live in the area (Kipsamoite or Kapsisiywa) for more than 6 months of the year, or, if they are new to the area, who plan to live in the area for more than 6 months of the year (permanent residents).

Passive surveillance of clinical malaria

-Any individual living within the boundaries of the 2 study areas (Kipsamoite and Kapsisiywa)

Exclusion Criteria:

Active surveillance of clinical malaria

  • Declining to participate in the study
  • Will be gone from site more than 1 week per month
  • Not available for weekly symptom check or bimonthly blood sample collection

Passive surveillance of clinical malaria

  • Declining to participate in the study
  • Participation in active surveillance study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00393757

Contacts
Contact: Chandy C John (612) 624-1966

Locations
Kenya
Kenya Medical Research Institute Recruiting
Kisumu, Kenya, 40100
Sponsors and Collaborators
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00393757     History of Changes
Obsolete Identifiers: NCT00776061
Other Study ID Numbers: 05-0124
Study First Received: October 26, 2006
Last Updated: August 26, 2010
Health Authority: Unspecified

Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
Malaria, Plasmodium falciparum, Kenya

Additional relevant MeSH terms:
Malaria
Malaria, Falciparum
Protozoan Infections
Parasitic Diseases

ClinicalTrials.gov processed this record on July 20, 2014