Malaria Transmission and Immunity in Highland Kenya
Recruitment status was Recruiting
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Purpose
The purpose of this study is to see why malaria epidemics occur in highland areas in Kenya. A better understanding of factors contributing to malaria may be necessary for malaria vaccine planning. These factors include interactions between age, where malaria is passed from mosquitoes to people, immune system (how the body fights infection) responses and other factors that contribute to malaria in epidemic-prone areas. About 6400 people from the villages of Kapsisiywa and Kipsamoite will participate. Study procedures will include in home surveys, which will involve a census and an interview by researchers. Blood samples and smears will be collected from some volunteers in both communities to understand how the body protects itself from malaria and to check for malaria parasites. Twice each month, random houses will be selected from 3 places in the village to measure the number of mosquitoes in the home. Participants may be involved in the study for up to 4 years.
| Condition |
|---|
|
Plasmodium Falciparum Malaria |
| Study Type: | Observational |
| Study Design: | Time Perspective: Prospective |
| Official Title: | Malaria Transmission and Immunity in Highland Kenya |
| Estimated Enrollment: | 6400 |
| Study Start Date: | October 2006 |
| Estimated Study Completion Date: | January 2010 |
The purpose of this study is to see why malaria epidemics occur in highland areas in Kenya. A better understanding of factors contributing to malaria may be necessary for malaria vaccine planning. These factors include interactions between age, where malaria is passed from mosquitoes to people, immune system (how the body fights infection) responses and other factors that contribute to malaria in epidemic-prone areas. About 6400 people from the villages of Kapsisiywa and Kipsamoite will participate. Study procedures will include in home surveys, which will involve a census and an interview by researchers. Blood samples and smears will be collected from some volunteers in both communities to understand how the body protects itself from malaria and to check for malaria parasites. Twice each month, random houses will be selected from 3 places in the village to measure the number of mosquitoes in the home. Participants may be involved in the study for up to 4 years.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Active surveillance of clinical malaria -Individuals of any age who live in the area (Kipsamoite or Kapsisiywa) for more than 6 months of the year, or, if they are new to the area, who plan to live in the area for more than 6 months of the year (permanent residents).
Passive surveillance of clinical malaria
-Any individual living within the boundaries of the 2 study areas (Kipsamoite and Kapsisiywa)
Exclusion Criteria:
Active surveillance of clinical malaria
- Declining to participate in the study
- Will be gone from site more than 1 week per month
- Not available for weekly symptom check or bimonthly blood sample collection
Passive surveillance of clinical malaria
- Declining to participate in the study
- Participation in active surveillance study
Contacts and Locations More Information
No publications provided
| ClinicalTrials.gov Identifier: | NCT00393757 History of Changes |
| Obsolete Identifiers: | NCT00776061 |
| Other Study ID Numbers: | 05-0124 |
| Study First Received: | October 26, 2006 |
| Last Updated: | August 26, 2010 |
| Health Authority: | Unspecified |
Keywords provided by National Institute of Allergy and Infectious Diseases (NIAID):
|
Malaria, Plasmodium falciparum, Kenya |
Additional relevant MeSH terms:
|
Malaria Malaria, Falciparum Protozoan Infections Parasitic Diseases |
ClinicalTrials.gov processed this record on May 16, 2013