White Matter in Pediatric Bipolar Disorder: A DTI Study
Fourteen subjects with bipolar disorder and 14 matching healthy controls, aged 6-13, will receive a magnetic resonance imaging (MRI) scan on a 3 Tesla scanner. They will also have a clinical interview, including the KSADS-PL. All subjects must be right-handed.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||White Matter Connectivity in Pediatric Bipolar Disorder: A Diffusion Tensor Imaging Study|
- Fractional anisotropy in brain white matter [ Time Frame: Baseline ] [ Designated as safety issue: No ]
|Study Start Date:||September 2005|
|Study Completion Date:||October 2008|
|Primary Completion Date:||September 2008 (Final data collection date for primary outcome measure)|
Children with bipolar disorder
Healthy comparison children
We propose to investigate the connectivity of white matter tracts using diffusion tensor imaging (DTI) in children with very early onset bipolar disorder (BPD). We hypothesize that the connectivity between the prefrontal cortex and the temporal lobe and parietal lobe and limbic structures will be abnormal, indicating white matter and gray matter deficits in early onset BPD. We also hypothesize that the superior lateral fasciculus cingulum bundle and the inferior lateral fasciculus will have decreased fractional anisotropy in very early onset BPD relative to healthy controls.
|United States, Massachusetts|
|Cambridge Health Alliance|
|Medford, Massachusetts, United States, 02155|
|Principal Investigator:||Jean A Frazier, MD||Cambridge Health Alliance|