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Metabolic Study of Concentric and Eccentric Muscle Training

This study has been completed.
Sponsor:
Information provided by:
Vorarlberg Institute for Vascular Investigation and Treatment
ClinicalTrials.gov Identifier:
NCT00386854
First received: October 10, 2006
Last updated: NA
Last verified: October 2006
History: No changes posted
  Purpose

The purpose of this study is to evaluate the metabolic and anti-inflammatory effects of eccentric endurance exercise and to compare them with those of concentric exercise in healthy sedentary individuals.


Condition Intervention
Lipid Metabolism
Insulin Resistance
Inflammation
 Behavioral: physical training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Educational/Counseling/Training

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Vorarlberg Institute for Vascular Investigation and Treatment:

Primary Outcome Measures:
  • Metabolic and anti-inflammatory effects induced by eccentric muscle exercise.

Secondary Outcome Measures:
  • Metabolic and anti-inflammatory effects induced by concentric muscle exercise.

Estimated Enrollment: 40
Study Start Date: April 2003
Estimated Study Completion Date: August 2003
Detailed Description:

Physical exercise decreases the risk of obesity, diabetes mellitus, and cardiovascular disease. Skeletal muscle can be exercised by two ways: Concentric contraction is defined as active shortening of muscles, e.g. by stepping upwards, whereas eccentric muscle contraction is defined as active resistance to stretching, e.g. by stepping downwards. Although the effects of exercise (i.e. the combination of concentric and eccentric muscle contraction) on metabolic parameters have been extensively investigated, there are no data on the specific metabolic effects of concentric versus those of eccentric muscle work in humans.

Comparison(s): Metabolic and anti-inflammatory effects of eccentric endurance exercise (i.e. stepping upwards), compared to metabolic and anti-inflammatory effects of concentric exercise (i.e. stepping downwards).

  Eligibility

Ages Eligible for Study:   30 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • healthy men and women
  • age over 30 years

Exclusion Criteria:

  • previous systematic endurance training (≥3 times per week ≥30 min)
  • body mass index >30 kg/m2
  • heavy smoking (>20 cigarettes per day)
  • regular alcohol consumption >60g per day
  • established musculoskeletal disease
  • history of cardiovascular disease
  • diabetes mellitus
  • unwillingness to stay in the area for the whole study period
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00386854

Locations
Austria
Vorarlberg Institute of Vascular Investigation and Treatment
Feldkirch, Vorarlberg, Austria, 6807
Sponsors and Collaborators
Vorarlberg Institute for Vascular Investigation and Treatment
Investigators
Principal Investigator: Heinz Drexel, MD Vorarlberg Institut of Vascular Investigation and Treatment, Academic Teaching Hospital, Austria
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00386854     History of Changes
Other Study ID Numbers: K01-2003-1
Study First Received: October 10, 2006
Last Updated: October 10, 2006
Health Authority: Austria: Ethikkommission

Keywords provided by Vorarlberg Institute for Vascular Investigation and Treatment:
exercise
lipid metabolism
lipoproteins
insulin resistance
inflammation

Additional relevant MeSH terms:
Inflammation
Insulin Resistance
Pathologic Processes
 Hyperinsulinism
Glucose Metabolism Disorders
Metabolic Diseases

ClinicalTrials.gov processed this record on May 23, 2013