Role of B2 Adrenergic Receptors in Labor Pain

This study has been completed.
Sponsor:
Information provided by:
Columbia University
ClinicalTrials.gov Identifier:
NCT00385294
First received: October 5, 2006
Last updated: October 1, 2010
Last verified: October 2010
  Purpose

We wish to understand why labor is more painful for some women compared to others.We will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.


Condition
Pain
Pain Threshold
Labour Pain

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Role of B2 Adrenergic Receptors in Labor Pain

Further study details as provided by Columbia University:

Biospecimen Retention:   Samples With DNA

DNA identified by subject number will be retained for analysis.


Enrollment: 150
Study Start Date: September 2006
Study Completion Date: January 2009
Primary Completion Date: January 2009 (Final data collection date for primary outcome measure)
Detailed Description:

Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. We will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. We will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Nuliparous women anticipating NSVD

Criteria

Inclusion Criteria:

  • nulliparous women
  • Third trimester of pregnancy on enrollment

Exclusion Criteria:

  • Chronic Pain
  • Pain medication utilization
  • Large for gestational age baby
  • Small for gestational age baby
  • Systemic illness
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00385294

Locations
United States, New York
Columbia University
New York, New York, United States, 10032
Sponsors and Collaborators
Columbia University
Investigators
Principal Investigator: Pamela D. Flood, M.D. Columbia University
  More Information

Publications:
Responsible Party: Pamela Flood, Columbia University
ClinicalTrials.gov Identifier: NCT00385294     History of Changes
Other Study ID Numbers: AAAB3535
Study First Received: October 5, 2006
Last Updated: October 1, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by Columbia University:
Genetic
pain
obstetrical

Additional relevant MeSH terms:
Labor Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on August 28, 2014