Role of B2 Adrenergic Receptors in Labor Pain
We wish to understand why labor is more painful for some women compared to others.We will study whether a woman's baseline pain sensitivity, beta2 adrenergic receptor genotype is related to her pain in labor for the birth of a first child.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Role of B2 Adrenergic Receptors in Labor Pain|
DNA identified by subject number will be retained for analysis.
|Study Start Date:||September 2006|
|Study Completion Date:||January 2009|
|Primary Completion Date:||January 2009 (Final data collection date for primary outcome measure)|
Other than parity, and infant size, the etiology of the great variability in labor pain us unknown. Previous studies have demonstrated that baseline pain sensitivity is related to postoperative pain and narcotic requirement. We hypothesize that baseline pain sensitivity is related to pain in labor. We will determine baseline sensitivity to heat, cold and pressure as measurement of pain sensitivity. Furthermore, b2 adrenergic genotype has recently been identified as a potential determinant of pain sensitivity. We will determine whether B2 receptor haplotype is an independent predictor of pain experienced in labor.