To Compare the Ischemic Pre-Conditioning and Post-Conditioning on Reperfusion Injury in Humans.
Reperfusion Injury occurs by the sudden blood flow to the injured and ischemic myocardium during restoration of blood flow either by Mechanical revascularization or thrombolysis. A phenomenon known as Pre-conditioning has been identified to limit the the extent and severity of reperfusion injury but it is very difficult to apply it in patient care setting as timing of acute cardiac or neurologic ischemic event is difficult to reliably predict.
Postconditioning or ischemic postconditioning is well known to attenuate the reperfusion injury. There is enough data that shows the benefit of post conditioning in reducing the reperfusion injury in animals. However postconditioning in humans has not been investigated.
We hypothesize that Post conditioning will attenuate the reperfusion injury and will be comparable to the effect of preconditioning in humans.
|Study Design:||Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:||The Mechanism of Ischemic Post Conditioning in Humans, Minimizing Reperfusion Injury.|
|Study Start Date:||May 2006|
|Estimated Study Completion Date:||August 2006|
|United States, Georgia|
|Emory University Hospital|
|Atlanta, Georgia, United States, 30322|
|Principal Investigator:||Tarek Helmy, MD||Emory University|
|Principal Investigator:||Arshed Ali Quyyumi, MD||Emory University|
|Study Director:||Muhammad Amer, MD||Emory University|