The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease

This study has been completed.
Sponsor:
Information provided by:
Aalborg Universitetshospital
ClinicalTrials.gov Identifier:
NCT00382551
First received: September 28, 2006
Last updated: January 29, 2009
Last verified: January 2009
  Purpose

To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.


Condition Intervention Phase
Coronary Heart Disease
Behavioral: Moderate daily consumption of Red wine
Behavioral: Moderate daily consumption of beer
Behavioral: Moderate consumption of fruit juice rich in polyphenolics
Phase 0

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Effect of Alcohol and Polyphenolic Compounds on Endothelial Function

Resource links provided by NLM:


Further study details as provided by Aalborg Universitetshospital:

Primary Outcome Measures:
  • Changes in flow-mediated vasodilation after 2 weeks intervention compared with baseline

Secondary Outcome Measures:
  • Lipid status after 2 weeks intervention compared with baseline
  • Effects in Coagulation factors after 2 weeks intervention
  • Effects on markers of inflammation after 2 weeks intervention
  • Effects on markers of endothelial function after 2 weeks intervention
  • Changes in the overall antioxidant activity in plasma after 2 weeks intervention

Enrollment: 49
Study Start Date: October 2006
  Eligibility

Ages Eligible for Study:   30 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Men or postmenopausal women with stable coronary heart disease
  • Coronary heart disease should be verified by coronary angiography with at least 50% stenosis in at least one coronary vessel.

Exclusion Criteria:

  • Patients with myocardial infarction within the last tree months
  • Persons with a present or earlier alcohol abuse
  • Persons with a present or earlier drug abuse
  • Person with malign disease
  • Persons, that we consider unsuitable to carry through the examines.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00382551

Locations
Denmark
Department of Cardiology, Aalborg Hospital, Science and Innovation Center
Aalborg, Denmark, 9000
Sponsors and Collaborators
Aalborg Universitetshospital
Investigators
Study Director: Erik B Schmidt, Professor Department of Cardiology, Aalborg Hospital , Aarhus University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00382551     History of Changes
Other Study ID Numbers: VN-20060043
Study First Received: September 28, 2006
Last Updated: January 29, 2009
Health Authority: Denmark: National Board of Health
Denmark: Ethics Committee

Keywords provided by Aalborg Universitetshospital:
Alcohol
Red wine
Endothelial function
Flow-mediated vasodilation
Cardiovascular disease

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Coronary Disease
Heart Diseases
Myocardial Ischemia
Arterial Occlusive Diseases
Arteriosclerosis
Vascular Diseases

ClinicalTrials.gov processed this record on October 23, 2014