The Effect of Beer, Red Wine and Fruit Juice on Blood Vessel Function in Persons With Cardiovascular Disease

This study has been completed.
Sponsor:
Information provided by:
Aalborg Universityhospital
ClinicalTrials.gov Identifier:
NCT00382551
First received: September 28, 2006
Last updated: January 29, 2009
Last verified: January 2009
  Purpose

To study the effect of red wine, beer and fruit juice on endothelial function in patients with coronary Heart disease.


Condition Intervention Phase
Coronary Heart Disease
Behavioral: Moderate daily consumption of Red wine
Behavioral: Moderate daily consumption of beer
Behavioral: Moderate consumption of fruit juice rich in polyphenolics
Phase 0

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: The Effect of Alcohol and Polyphenolic Compounds on Endothelial Function

Resource links provided by NLM:


Further study details as provided by Aalborg Universityhospital:

Primary Outcome Measures:
  • Changes in flow-mediated vasodilation after 2 weeks intervention compared with baseline

Secondary Outcome Measures:
  • Lipid status after 2 weeks intervention compared with baseline
  • Effects in Coagulation factors after 2 weeks intervention
  • Effects on markers of inflammation after 2 weeks intervention
  • Effects on markers of endothelial function after 2 weeks intervention
  • Changes in the overall antioxidant activity in plasma after 2 weeks intervention

Enrollment: 49
Study Start Date: October 2006
  Eligibility

Ages Eligible for Study:   30 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Men or postmenopausal women with stable coronary heart disease
  • Coronary heart disease should be verified by coronary angiography with at least 50% stenosis in at least one coronary vessel.

Exclusion Criteria:

  • Patients with myocardial infarction within the last tree months
  • Persons with a present or earlier alcohol abuse
  • Persons with a present or earlier drug abuse
  • Person with malign disease
  • Persons, that we consider unsuitable to carry through the examines.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00382551

Locations
Denmark
Department of Cardiology, Aalborg Hospital, Science and Innovation Center
Aalborg, Denmark, 9000
Sponsors and Collaborators
Aalborg Universityhospital
Investigators
Study Director: Erik B Schmidt, Professor Department of Cardiology, Aalborg Hospital , Aarhus University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00382551     History of Changes
Other Study ID Numbers: VN-20060043
Study First Received: September 28, 2006
Last Updated: January 29, 2009
Health Authority: Denmark: National Board of Health
Denmark: Ethics Committee

Keywords provided by Aalborg Universityhospital:
Alcohol
Red wine
Endothelial function
Flow-mediated vasodilation
Cardiovascular disease

Additional relevant MeSH terms:
Cardiovascular Diseases
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on April 17, 2014