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Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2007 by Hadassah Medical Organization.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00382369
First received: September 28, 2006
Last updated: May 12, 2008
Last verified: November 2007
History of Changes
  Purpose

Vocal cord paralysis is a common cause of congenital stridor and airway obstruction. In this study we plan to identify the genetic locus of the genes in two extended families who suffer of the disease.


Condition
Vocal Cord Paralysis

Study Type: Observational
Study Design: Observational Model: Family-Based
Time Perspective: Prospective
Official Title: Whole Genome Scan of Extended Families With Familial Vocal Cord Paralysis

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention:   Samples With DNA

DNA prepared from blood


Estimated Enrollment: 60
Study Start Date: May 2005
Estimated Study Completion Date: December 2007
Detailed Description:

In a number of families suffering of familial vocal cord paralysis it has previously been shown that the disease is inherited autosomal dominant. In one of the families the gene coding for the disease was located on chromosome 6q16. We will be analyzing 2 extended families with familial vocal cord paralysis to define their genetic defect leading to the disease. All family members will undergo a laryngoscopy to determine the extent of paralysis. For all family members we will isolate DNA and determine their microsatellite polymorphism on chromosome 6q16. If the results are negative we will continue the study and perform a whole genome scan to localize the gene(s) involved.

  Eligibility

Ages Eligible for Study:   10 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Families suffering of familial vocal cord paralysis

Criteria

Inclusion Criteria:

  • members of families suffering of familial vocal cord paralysis

Exclusion Criteria:

  • none
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00382369

Contacts
Contact: Eitan Kerem, MD 972-2-5844430 kerem@hadassah.org.il

Locations
Israel
Hadassah-Hebrew University Medical Center, Mt Scopus Recruiting
Jerusalem, Israel, 24035
Contact: Arik Tzukert, DMD     00 972 2 6776095     arik@hadassah.org.il    
Contact: Hadas Lemberg, PhD     00 972 2 6777572     lhadas@hadassah.org.il    
Sub-Investigator: Ariela Simon, MD            
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Study Director: Eitan Kerem, MD Hadassah MO
Principal Investigator: Batsheva Kerem, PhD Hebrew University Jerusalem
  More Information

Publications:

Responsible Party: Prof Eitan Kerem, Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00382369     History of Changes
Other Study ID Numbers: VOCALCORD-HMO-CTIL
Study First Received: September 28, 2006
Last Updated: May 12, 2008
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:
familial vocal cord paralysis
genetic screening

Additional relevant MeSH terms:
Vocal Cord Paralysis
Paralysis
Laryngeal Diseases
Respiratory Tract Diseases
Otorhinolaryngologic Diseases
 Vagus Nerve Diseases
Cranial Nerve Diseases
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms

ClinicalTrials.gov processed this record on June 18, 2013