The Combined Effect of 2,3-Dimercaptosuccinic Acid and Multi-Nutrients on Children in Lead Poisoning

This study has been completed.
Information provided by:
China Medical University, China Identifier:
First received: September 11, 2006
Last updated: NA
Last verified: April 2004
History: No changes posted

Lead poisoning remains a common disease among children despite successful public health efforts that reduced its prevalence.Our study was designed to test the hypothesis that lead-poisoning children (BLLs:100-440µg/L) who were given DMSA and multi-nutrients would have a greater fall than children of other groups at 12 weeks of follow-up.

Condition Intervention
Lead Poisoning
Drug: 2,3-dimercaptosuccinic acid

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal

Resource links provided by NLM:

Further study details as provided by China Medical University, China:

Estimated Enrollment: 500
Study Start Date: March 2004
Estimated Study Completion Date: August 2004

Ages Eligible for Study:   3 Years to 6 Years
Genders Eligible for Study:   Both

Inclusion Criteria:

  • Initial BLLs 100-440µg/L
  • Age 3-6y
  • No more than two main residences
  • House cleaned (no lead contaminated)
  • Normal intake history and physical

Exclusion Criteria:

  • Chelation in the past 12 weeks
  • Concomitant Fe deficiency(ferritin<16ng/ml)
  • Hemoglobin<10.5g/dL
  • Medications affecting mineral metabolism
  Contacts and Locations
Please refer to this study by its identifier: NCT00374894

China, Liaoning
China Medical University
Shenyang, Liaoning, China, 110001
Sponsors and Collaborators
China Medical University, China
Study Director: Jin Ya ping, professor Department of Environmental and Occupational Health
  More Information

No publications provided Identifier: NCT00374894     History of Changes
Other Study ID Numbers: 20032063 - 2001102049
Study First Received: September 11, 2006
Last Updated: September 11, 2006
Health Authority: China: Ministry of Health

Keywords provided by China Medical University, China:
2,3-dimercaptosuccinic acid
Blood Lead Levels

Additional relevant MeSH terms:
Lead Poisoning
Substance-Related Disorders
Chelating Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Protective Agents
Physiological Effects of Drugs processed this record on April 21, 2014