Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

This study has been completed.
Sponsor:
Information provided by:
Danish Headache Center
ClinicalTrials.gov Identifier:
NCT00374530
First received: September 8, 2006
Last updated: July 31, 2007
Last verified: July 2007
  Purpose

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.


Condition Intervention
Headache
Migraine
Drug: PGE2

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double-Blind
Official Title: Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Resource links provided by NLM:


Further study details as provided by Danish Headache Center:

Primary Outcome Measures:
  • Headache

Secondary Outcome Measures:
  • rCBF, blood flow, diameter of STA/RA, HR, BP

Estimated Enrollment: 12
Study Start Date: August 2006
  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers

Exclusion Criteria:

  • Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00374530

Locations
Denmark
Danish Headache Center
Glostrup, Denmark, DK-2600
Sponsors and Collaborators
Danish Headache Center
Investigators
Principal Investigator: Troels Wienecke, MD Danish Headache Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00374530     History of Changes
Other Study ID Numbers: KA-20060026
Study First Received: September 8, 2006
Last Updated: July 31, 2007
Health Authority: Denmark: Ethics Committee

Additional relevant MeSH terms:
Headache
Nervous System Diseases
Neurologic Manifestations
Pain
Signs and Symptoms

ClinicalTrials.gov processed this record on October 20, 2014