Patients:

Inclusion Criteria:

• DSM-IV diagnosis of Anorexia Nervosa
• BMI ≤ 17.5kg/m2 (equivalent to 80% of ideal body weight)
• Medically stable
• Participation in in-patient treatment sufficient to restore patient to a BMI of at least 19kg/m2

Exclusion Criteria:

• On medication*
• Current substance abuse or dependence
• History of suicide attempt or other self-injurious behavior within the previous 6 months
• Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)

Controls:

Inclusion criteria:

• No current psychiatric disorder (including eating disorder, depression, bipolar disorder, schizophrenia, substance abuse/dependence)
• No history of an eating disorder
• BMI greater than 19kg/m2 and less than 21kg/m2
• Weight stable (+/- 2kg) for the previous 6 months
• No history of excessive or repeated dieting
• No history of excessive exercise (defined as greater than 6 hours/week)
• Regular menstrual cycles

Exclusion criteria:

• On medication*
• Pregnant or lactating
• Significant medical problem

• Non-removable metal on/in their body (e.g. metal pacemaker, surgical clips, metallic-ink tattoos)

  • At the time of testing, subjects will be free of fluoxetine for 6 weeks, and free of all other medications for a minimum of 2 weeks