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Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

This study has been completed.
Sponsor:
Information provided by:
Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT00360048
First received: August 2, 2006
Last updated: December 10, 2007
Last verified: December 2007
History of Changes
  Purpose

The aim of this study is to determine if oxytocin administration is able to blunt LPS induced increase of cytokines (TNF-α) and if there is a change in the endocrine response after lipopolysaccharide administration in humans.


Condition Intervention
Sepsis
 Drug: oxytocin

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Oxytocin Effects on Cytokines and Endocrine Parameters After LPS Induced Systemic Inflammatory Effects in Healthy Volunteers

Resource links provided by NLM:

MedlinePlus related topics: Sepsis
Drug Information available for: Oxytocin
U.S. FDA Resources

Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • TNF-alpha [ Time Frame: six hours ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • ACTH, cortisol, procalcitonin, IL-1ra, IL-4, IL-6, MIP-1alpha, MIP-1 beta, MCP-1, IP-10, VEGF, body temperature, BNP, Ghrelin, [ Time Frame: six hours ] [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: August 2006
  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Men aged 18 years or older with no disease history
  • Written informed consent

Exclusion Criteria:

  • Receiving any medication
  • Probands who suffer from infectious disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00360048

Locations
Austria
Medical University of Vienna
Vienna, Austria, 1090
Sponsors and Collaborators
Medical University of Vienna
Investigators
Principal Investigator: Martin Clodi, MD, Associate Professor Medical University of Vienna
  More Information

No publications provided by Medical University of Vienna

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

ClinicalTrials.gov Identifier: NCT00360048     History of Changes
Other Study ID Numbers: 2006-000246-39, EK-Nr.: 014/2006
Study First Received: August 2, 2006
Last Updated: December 10, 2007
Health Authority: Austria: Federal Ministry for Health and Women

Keywords provided by Medical University of Vienna:
oxytocin
tnf
sepsis
lps

Additional relevant MeSH terms:
Sepsis
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes
Oxytocin
 Oxytocics
Reproductive Control Agents
Physiological Effects of Drugs
Pharmacologic Actions
Therapeutic Uses

ClinicalTrials.gov processed this record on June 18, 2013