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Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

This study has been completed.
Sponsor:
Information provided by:
Danish Headache Center
ClinicalTrials.gov Identifier:
NCT00357864
First received: July 26, 2006
Last updated: August 29, 2007
Last verified: August 2007
History of Changes
  Purpose

To investigate headache score and accompanying symptoms during and after infusion of carbachol.


Condition Intervention
Headache
 Drug: carbachol

Study Type: Observational
Study Design: Additional Descriptors: Convenience Sample
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Basic Research on Carbachol´s Headache Inducing Characteristics and Effects on the Cerebral Blood Flow in a Humane Experimental Headache Model

Resource links provided by NLM:

MedlinePlus related topics: Headache
Drug Information available for: Carbachol
U.S. FDA Resources

Further study details as provided by Danish Headache Center:

Enrollment: 15
Study Start Date: July 2006
Study Completion Date: April 2007
Detailed Description:

To investigate headache score and accompanying symptoms during and after infusion of carbachol.

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

  Eligibility

Ages Eligible for Study:   18 Years to 40 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy volunteers
  • Aged 18-40
  • 50-100 kg
  • Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria:

  • Tension type headache more than once/month
  • Other primary headaches
  • Daily medication except contraceptives
  • Drug taken within 4 times the halflife for the specific drug except contraceptives
  • Pregnant or lactating women
  • Exposure to radiation within the last year
  • Headache within the last 24 hours before start of trial
  • Hypertension
  • Hypotension
  • Respiratory or cardiac disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00357864

Locations
Denmark
Dansih Headache Center
Glostrup, Denmark, 2600
Sponsors and Collaborators
Danish Headache Center
Investigators
Principal Investigator: henrik schytz Danish Headache Center
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00357864     History of Changes
Other Study ID Numbers: 2006-002462-19
Study First Received: July 26, 2006
Last Updated: August 29, 2007
Health Authority: Denmark: Danish Medicines Agency

Additional relevant MeSH terms:
Headache
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Carbachol
Cardiotonic Agents
Cardiovascular Agents
Therapeutic Uses
Pharmacologic Actions
Miotics
Autonomic Agents
 Peripheral Nervous System Agents
Physiological Effects of Drugs
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Central Nervous System Agents
Protective Agents

ClinicalTrials.gov processed this record on May 19, 2013