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Arterial Stiffness, Wave Reflections and Renal Failure

This study has been completed.
Sponsor:
Information provided by:
Klinikum Wels-Grieskirchen
ClinicalTrials.gov Identifier:
NCT00354588
First received: July 19, 2006
Last updated: November 3, 2010
Last verified: November 2010
History of Changes
  Purpose
  1. Cardiovascular risk is high in patients with renal failure.
  2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function. However, there are no prospective longitudinal studies in the literature.
  3. In dialysis patients, arterial stiffness as well as wave reflections, predict mortality. However, there are no data on patients with mild-to-moderate renal impairment available.
  4. Therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure

Condition
Chronic Renal Failure
Arterial Stiffness
Arterial Wave Reflections

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Observational Study on the Prognostic Significance (Renal and Cardiovascular) of Arterial Stiffness and Arterial Wave Reflections in Patients With Mild to Moderate Renal Impairment

Resource links provided by NLM:

MedlinePlus related topics: Kidney Failure
U.S. FDA Resources

Further study details as provided by Klinikum Wels-Grieskirchen:

Primary Outcome Measures:
  • renal endpoint [ Designated as safety issue: No ]
    doubling serum creatinine, need for dialysis, renal transplantation


Enrollment: 115
Study Start Date: January 2006
Study Completion Date: October 2010
Primary Completion Date: October 2010 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   19 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

patients with chronic renal failure

Criteria

Inclusion Criteria:

  • chronic renal failure patients (KDOQI III, IV) undergoing regular control visits at our nephrology department
  • > 19 years
  • written informed consent

Exclusion Criteria:

  • atrial fibrillation
  • valvular heart disease
  • severely impaired systolic function
  • no informed consent
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00354588

Locations
Austria
Cardiology and Nephrology Department Klinikum Wels
Wels, Austria, 4600
Sponsors and Collaborators
Klinikum Wels-Grieskirchen
Investigators
Principal Investigator: Thomas Weber, MD Cardiology Department, Klinikum Wels, Austria
Principal Investigator: Manfred Wallner, MD Nephrology Department, Klinikum Wels, Austria
  More Information

No publications provided

Responsible Party: Thomas Weber, MD, Klinikum Wels-Grieskirchen
ClinicalTrials.gov Identifier: NCT00354588     History of Changes
Other Study ID Numbers: WelsEK 206
Study First Received: July 19, 2006
Last Updated: November 3, 2010
Health Authority: Austria: Government of Upper Austria, Social Department

Keywords provided by Klinikum Wels-Grieskirchen:
chronic renal failure
arterial stiffness
arterial wave reflections

Additional relevant MeSH terms:
Kidney Failure, Chronic
Renal Insufficiency
Renal Insufficiency, Chronic
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on May 21, 2013