Coronary Atherosclerosis Evaluation by Arterial Wall Magnetic Resonance Imaging (MRI)

This study has been completed.
Sponsor:
Collaborator:
Northwestern University
Information provided by:
Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT00353795
First received: July 18, 2006
Last updated: May 25, 2010
Last verified: September 2009
  Purpose

The overall goal of this study is to use MRI to:

  • Examine the relationship between known risk factors for cardiovascular disease and coronary artery wall thickness;
  • Examine the relationship between coronary artery wall thickness and other markers of subclinical coronary atherosclerosis, such as carotid wall thickness and coronary calcium scores; and,
  • Examine the feasibility of measuring the progression of coronary artery wall thickness over time in a subset of participants.

Condition Intervention
Coronary Arteriosclerosis
Arteriosclerosis, Coronary
Atherosclerosis, Coronary
Coronary Artery Disease
Coronary Atherosclerosis
Procedure: MR Imaging of the Coronary Arteries

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Coronary Atherosclerosis Evaluation by Arterial Wall MRI

Resource links provided by NLM:


Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • Mean Coronary Wall Thickness [ Time Frame: n/a (cross sectional analysis) ] [ Designated as safety issue: No ]
    Average thickness of the wall of the left anterior descending, right and left main coronary artery measured by magnetic resonance imaging (MRI).


Enrollment: 179
Study Start Date: July 2005
Study Completion Date: June 2008
Primary Completion Date: June 2008 (Final data collection date for primary outcome measure)
Detailed Description:

Each enrolled participant will undergo MR Imaging of the coronary arteries in conjunction with their routine MESA follow-up visit. The MRI will last approximately 45-60 minutes

  Eligibility

Ages Eligible for Study:   45 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Prior enrollment in the MESA Study at the Hopkins MESA Field Center or the Northwestern University MESA Field Center
  • Male or Female adult equal to or older than 45 years of age
  • Willing/able to provide informed consent

Exclusion Criteria:

  • Any known contraindications to MRI (i.e. severe claustrophobia, pacemaker, etc.)
  • Metal in the eyes
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00353795

Locations
United States, Illinois
Northwestern University MESA Field Center
Chicago, Illinois, United States, 60611
United States, Maryland
Johns Hopkins MESA Field Center
Baltimore, Maryland, United States, 21244
Sponsors and Collaborators
Johns Hopkins University
Northwestern University
Investigators
Principal Investigator: David A Bluemke, MD PhD Johns Hopkins University
  More Information

Additional Information:
No publications provided

ClinicalTrials.gov Identifier: NCT00353795     History of Changes
Other Study ID Numbers: 05-05-23-01, 5R01HL078909
Study First Received: July 18, 2006
Results First Received: August 4, 2009
Last Updated: May 25, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by Johns Hopkins University:
MESA
MRI
Cardiovascular
Cardiac
Coronary
Atherosclerosis

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Atherosclerosis
Arteriosclerosis
Heart Diseases
Cardiovascular Diseases
Arterial Occlusive Diseases
Vascular Diseases

ClinicalTrials.gov processed this record on September 18, 2014