Determining the Response to Sipping Beverages Without Swallowing in People With Eating Disorders

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
New York State Psychiatric Institute
ClinicalTrials.gov Identifier:
NCT00353548
First received: July 14, 2006
Last updated: July 20, 2012
Last verified: July 2012
  Purpose

This study will use a sipping and spitting exercise to better understand the brain's response to food intake in people with eating disorders.


Condition
Eating Disorders

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Study of Response to the Taste of Beverages That Are Not Swallowed (Sipping and Spitting in Eating Disorders)

Resource links provided by NLM:


Further study details as provided by New York State Psychiatric Institute:

Enrollment: 80
Study Start Date: April 2005
Study Completion Date: July 2011
Primary Completion Date: July 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
1-Anorexia Nervosa
Women ages 16-50 who meet DSM-IV criteria for anorexia nervosa
2-Bulimia Nervosa
Women age 16-50 who meet DSM-IV criteria for bulimia nervosa
3-Binge Eating Disorder
Women with binge eating disorder
4-Healthy Controls
Healthy control subjects ages 16-50 of normal weight
5-Obese Controls
Healthy obese control subjects

Detailed Description:

Eating behavior is controlled by many factors, including appetite; food availability; family, peer, and cultural practices; and attempts at voluntary control. Eating disorders are characterized by a voluntary control of eating behavior, causing serious disturbances in normal eating habits. People with eating disorders demonstrate an extreme and unhealthy reduction or increase in food intake, as well as feelings of distress or extreme concern about body shape or weight. The three most common types of eating disorders are anorexia nervosa, bulimia nervosa, and binge eating disorder. People with anorexia nervosa have an intense fear of gaining weight or becoming fat. They are usually underweight, and resist maintaining a body weight at or above the minimum normal weight for their age and height. People with bulimia nervosa are less frequently underweight. Their eating habits are characterized by episodes of bingeing, followed by episodes of purging. Similarly, people with binge eating disorder have eating habits characterized by episodes of binge eating, but no purging. Studies on the basic biology of appetite control and the effects of overeating and starvation have revealed extensive information about eating disorders, but there are still questions to be answered. This study will use a sipping and spitting exercise to better understand the brain's response to food intake in people with eating disorders.

Participants in this observational study will first report to the Biological Studies Unit (BSU) for a screening visit. Participants will be provided with a series of sweetened beverages to taste and spit out. The beverages will be made with water, Kool-Aid mix, and sugar or artificial sweetener. Participants will rate the sweetness of each beverage and how much they like it. They will then practice sipping the beverage through a straw and spitting it out without swallowing. Those participants who feel comfortable with the sipping and spitting exercise will report to the BSU for 10 sipping and spitting exercises. The exercises may be scheduled on up to 4 separate days, and may last up to 2 hours per day. Participants will eat a standardized breakfast on the morning of the study, and then will not eat again until they report to the BSU 4 hours later. Participants will sit alone in a room alone, and sip and spit beverages for up to 5 minutes at a time. Between sipping and spitting sessions, participants will complete surveys about hunger and other sensations. They will also rinse their mouths out with baking soda and water to clear the taste of the previous beverage and to prevent discoloration of the mouth from the Kool-Aid. Measurements will include the amount of beverage sipped at a time, and how quickly each was sipped.

  Eligibility

Ages Eligible for Study:   16 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Women with anorexia nervosa, bulimia nervosa, and binge eating disorder as well as gender, age, and weight-matched control participants.

Criteria

Inclusion Criteria:

For participants with bulimia nervosa:

  • Meets DSM-IV criteria for bulimia nervosa
  • Duration of illness is 1 year
  • Self-induces vomiting
  • Weighs between 85 and 120% of ideal weight

For participants with anorexia nervosa:

  • Meets DSM-IV criteria for anorexia nervosa (amenorrhea will not be required for study inclusion)
  • Medically stable

For participants with binge eating disorder:

  • Meets DSM-IV criteria for binge eating disorder
  • Duration of illness is 1 year
  • Body Mass Index (BMI) is at least 30

For healthy participants:

  • Weighs between 80 and 120% of ideal weight

Exclusion Criteria:

For participants with anorexia nervosa, bulimia nervosa, or binge eating disorder:

  • Significant medical illness
  • At risk for suicide
  • Currently taking medication
  • History of drug or alcohol abuse within 6 months prior to study entry
  • Pregnant or breastfeeding
  • Axis I psychiatric disorder requiring pharmacotherapy
  • Axis I psychiatric disorder that could impair ability to participate in the study (e.g., mania, psychosis)
  • Comorbid binge eating disorder and an Axis I illness other than major depression

For healthy participants:

  • Current or history of psychiatric illness
  • History of any eating disorder
  • Significant medical illness
  • Currently taking medication
  • History of drug or alcohol abuse within 6 months prior to study entry
  • Pregnant or breastfeeding
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00353548

Locations
United States, New York
New York State Psychiatric Institute/Columbia University Medical Center
New York, New York, United States, 10032
Sponsors and Collaborators
New York State Psychiatric Institute
Investigators
Principal Investigator: Diane A. Klein, MD Columbia University Department of Psychiatry/New York State Psychiatric Institute
  More Information

No publications provided

Responsible Party: New York State Psychiatric Institute
ClinicalTrials.gov Identifier: NCT00353548     History of Changes
Other Study ID Numbers: #5046/#6158R, K23MH071285-01, DATR AK-TNAI1
Study First Received: July 14, 2006
Last Updated: July 20, 2012
Health Authority: United States: Federal Government

Keywords provided by New York State Psychiatric Institute:
Bulimia Nervosa
Binge Eating Disorder
Obesity
Anorexia Nervosa

Additional relevant MeSH terms:
Eating Disorders
Mental Disorders

ClinicalTrials.gov processed this record on August 27, 2014