Cytogenetic Study of Ocular Melanoma
Recruitment status was Recruiting
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Purpose
Patients who are diagnosed with choroidal melanoma and undergo I-125 plaque or enucleation surgery consent to participate in the study. A tumor sample taken during surgery is studied in the lab for genetic features. These features and features of subjects' clinical course are recorded. Analysis of the data may identify genetic features that are indicative of prognostic factors including risk of metastasis.
| Condition |
|---|
|
Choroidal Melanoma |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Molecular and Cytogenetic Studies of Ocular Melanoma |
| Estimated Enrollment: | 200 |
| Study Start Date: | April 2005 |
The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients who have been diagnosed with ocular melanoma, and underwent melanoma treatment at our facility.
Inclusion Criteria:
- Patient with diagnosis of ocular melanoma
- Patient with local treatment plan for ocular melanoma- plaque brachytherapy or enucleation
- Patient 18 years of age or older
- Archival enucleation specimens with diagnosis of ocular melanoma
Exclusion Criteria:
- Patient who refuses local melanoma treatment
- Patient who refuses to participate in this study
Contacts and Locations| Contact: Tara A McCannel, MD, PhD | 310-206-7484 | tmccannel@jsei.ucla.edu |
| Contact: Sandy Yin, M.S. | 310 206 7484 | yin@jsei.ucla.edu |
| United States, California | |
| Jules Stein Eye Institute | Recruiting |
| Los Angeles, California, United States, 90095 | |
| Contact: sandy yin 310-206-7484 yin@jsei.ucla.edu | |
| Principal Investigator: | Tara M McCannel, MD, PhD | Jules Stein Eye Institute, UCLA |
| Study Director: | Bradley R Straatsma, MD, JD | Jules Stein Eye Institute, UCLA |
| Study Chair: | Lynn Gordon, MD, PhD | Jules Stein Eye Institute, UCLA |
| Study Chair: | Ben Glasgow, MD | Jules Stein Eye Institute, UCLA |
| Study Chair: | Nagesh P Rao, PhD | UCLA Pathology and Laboratory Medicine |
More Information
No publications provided by University of California, Los Angeles
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| Responsible Party: | Tara McCannel, M.D., Ph.D., University of California, Los Angeles |
| ClinicalTrials.gov Identifier: | NCT00344799 History of Changes |
| Other Study ID Numbers: | UCLA IRB#04-12-084 |
| Study First Received: | June 26, 2006 |
| Last Updated: | June 17, 2010 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by University of California, Los Angeles:
|
Choroidal Melanoma Choroidal Malignant Melanoma Ocular Melanoma Uveal Melanoma |
Additional relevant MeSH terms:
|
Melanoma Neuroendocrine Tumors Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal |
Neoplasms by Histologic Type Neoplasms Neoplasms, Nerve Tissue Nevi and Melanomas |
ClinicalTrials.gov processed this record on June 18, 2013