Cytogenetic Study of Ocular Melanoma

The recruitment status of this study is unknown because the information has not been verified recently.
Verified February 2009 by University of California, Los Angeles.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
University of California, Los Angeles
ClinicalTrials.gov Identifier:
NCT00344799
First received: June 26, 2006
Last updated: June 17, 2010
Last verified: February 2009
  Purpose

Patients who are diagnosed with choroidal melanoma and undergo I-125 plaque or enucleation surgery consent to participate in the study. A tumor sample taken during surgery is studied in the lab for genetic features. These features and features of subjects' clinical course are recorded. Analysis of the data may identify genetic features that are indicative of prognostic factors including risk of metastasis.


Condition
Choroidal Melanoma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Molecular and Cytogenetic Studies of Ocular Melanoma

Resource links provided by NLM:


Further study details as provided by University of California, Los Angeles:

Estimated Enrollment: 200
Study Start Date: April 2005
Detailed Description:

The Jules Stein Eye Institute Ocular Melanoma Research Group is conducting cytogenetic studies of choroidal melanoma to improve the screening of biopsy samples of choroidal melanoma through cytogenetic analysis. Our goal is to identify molecular probes that specifically target regions of chromosomes that undergo changes characteristic of metastatic choroidal melanoma.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients who have been diagnosed with ocular melanoma, and underwent melanoma treatment at our facility.

Criteria

Inclusion Criteria:

  1. Patient with diagnosis of ocular melanoma
  2. Patient with local treatment plan for ocular melanoma- plaque brachytherapy or enucleation
  3. Patient 18 years of age or older
  4. Archival enucleation specimens with diagnosis of ocular melanoma

Exclusion Criteria:

  1. Patient who refuses local melanoma treatment
  2. Patient who refuses to participate in this study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00344799

Contacts
Contact: Tara A McCannel, MD, PhD 310-206-7484 tmccannel@jsei.ucla.edu
Contact: Sandy Yin, M.S. 310 206 7484 yin@jsei.ucla.edu

Locations
United States, California
Jules Stein Eye Institute Recruiting
Los Angeles, California, United States, 90095
Contact: sandy yin    310-206-7484    yin@jsei.ucla.edu   
Sponsors and Collaborators
University of California, Los Angeles
Investigators
Principal Investigator: Tara M McCannel, MD, PhD Jules Stein Eye Institute, UCLA
Study Director: Bradley R Straatsma, MD, JD Jules Stein Eye Institute, UCLA
Study Chair: Lynn Gordon, MD, PhD Jules Stein Eye Institute, UCLA
Study Chair: Ben Glasgow, MD Jules Stein Eye Institute, UCLA
Study Chair: Nagesh P Rao, PhD UCLA Pathology and Laboratory Medicine
  More Information

No publications provided by University of California, Los Angeles

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Tara McCannel, M.D., Ph.D., University of California, Los Angeles
ClinicalTrials.gov Identifier: NCT00344799     History of Changes
Other Study ID Numbers: UCLA IRB#04-12-084
Study First Received: June 26, 2006
Last Updated: June 17, 2010
Health Authority: United States: Institutional Review Board

Keywords provided by University of California, Los Angeles:
Choroidal Melanoma
Choroidal Malignant Melanoma
Ocular Melanoma
Uveal Melanoma

Additional relevant MeSH terms:
Melanoma
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Nerve Tissue
Nevi and Melanomas

ClinicalTrials.gov processed this record on April 17, 2014