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Appetite-Related Brain Activity in Women With Anorexia Nervosa

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
New York State Psychiatric Institute
ClinicalTrials.gov Identifier:
NCT00344656
First received: June 23, 2006
Last updated: April 18, 2012
Last verified: April 2012
  Purpose

This study will use functional magnetic resonance imaging to compare appetite-related brain activity in women with anorexia nervosa before and after receiving treatment for the disorder.


Condition
Eating Disorders
Anorexia Nervosa

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Study of Appetite-Related Brain Activity With Functional Magnetic Resonance Imaging in Women With Anorexia Nervosa

Resource links provided by NLM:


Further study details as provided by New York State Psychiatric Institute:

Enrollment: 15
Study Start Date: October 2004
Study Completion Date: October 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
Subjects and Controls
Patients with DSM-IV Anorexia Nervosa

Detailed Description:

Anorexia nervosa (AN) is a serious eating disorder that is characterized by an extreme loss of appetite. People with AN view themselves as overweight and cannot bring themselves to eat, even though most are dangerously thin. Functional magnetic resonance imaging (fMRI) is a technique that can be used to determine which parts of the brain are activated by physical stimuli. When a certain stimulus is introduced, blood flow to the corresponding area of the brain increases. This increase in blood flow is depicted on the fMRI scan. A person with AN may have different responses to food when evaluated prior to treatment versus after treatment. This study will use fMRI to compare appetite-related brain activity in women with AN before and after receiving treatment for the disorder.

Participants in this study will undergo two fMRI scans. Participants with AN will have one scan before entering the "weight gain phase" of treatment for AN and another scan upon completion of treatment. Healthy volunteers will undergo scans during a similar time frame. Participants will not be allowed to eat from midnight on the night before the scan until after the fMRI procedure, but they may drink water. During the scan, participants will be shown various objects and real foods; they will also be asked to touch the objects and food with their eyes closed. Each visit will last approximately 45 minutes. Ear protectors will be provided to reduce scanner noise.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Women with AN between 18 and 45 years of age hospitalized for treatment of anorexia nervosa.

Criteria

Inclusion Criteria:

For Participants with AN:

  • DSM-IV diagnosis of AN (restricting or binge eating/purging subtype)
  • Medically stable (not continuing to lose weight and vital signs stable)

For Healthy Participants:

  • Currently weighs 80-120% of ideal weight
  • no history of binge eating disorder or vomiting
  • no current or past psychiatric illness

Exclusion Criteria:

For Participants with AN:

  • Currently taking medication
  • Current substance abuse or dependence disorder
  • History of suicide attempt or other self-injurious behavior within 6 months prior to study entry
  • Non-removable metal on or inside the body (e.g., metal pacemaker, surgical clips, metallic-ink tattoos)

For Healthy Participants:

  • Current or past psychiatric illness
  • History of binge eating or vomiting
  • Any significant medical or neurologic illness
  • Currently taking medication
  • History of drug or alcohol abuse within 3 months prior to study entry
  • Non-removable metal on or inside the body (e.g., metal pacemaker, surgical clips, metallic-ink tattoos)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00344656

Locations
United States, New York
New York State Psychiatric Institute
New York, New York, United States, 10032
Sponsors and Collaborators
New York State Psychiatric Institute
Investigators
Principal Investigator: Laurel Mayer, MD New York State Psychiatric Institute
  More Information

No publications provided

Responsible Party: New York State Psychiatric Institute
ClinicalTrials.gov Identifier: NCT00344656     History of Changes
Other Study ID Numbers: #4850
Study First Received: June 23, 2006
Last Updated: April 18, 2012
Health Authority: United States: Federal Government

Keywords provided by New York State Psychiatric Institute:
Eating Disorders
Anorexia Nervosa

Additional relevant MeSH terms:
Anorexia
Anorexia Nervosa
Eating Disorders
Mental Disorders
Signs and Symptoms
Signs and Symptoms, Digestive

ClinicalTrials.gov processed this record on November 20, 2014