Personality-targeted Interventions for Adolescent Alcohol Misuse - Full Text View

Purpose

Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press). As these interventions target personality traits linked to risk for addictive and non-addictive mental disorders, the aim of this study is to examine the extent to which this approach can prevent and/or reduce alcohol and drug misuse as well as have an impact on the onset or severity of emotional and behavioural problems in young people.

Condition	Intervention	Phase
Alcohol Abuse Drug Abuse Depression Panic Disorder Conduct Disorder	Behavioral: PRE-Venture: Personality Risk Education	Phase 2 Phase 3

Study Type:	Interventional
Study Design:	Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Factorial Assignment Masking: Open Label Primary Purpose: Prevention
Official Title:	A New School-based Drug Prevention Programme for Teenagers: Interventions That Target Personality Risk for Substance Abuse and Mental Illness

Resource links provided by NLM:

MedlinePlus related topics: Anxiety Child Mental Health Depression Mental Disorders Panic Disorder

U.S. FDA Resources

Further study details as provided by King's College London:

Primary Outcome Measures:

Time to onset and severity of drug use [ Time Frame: 2 years ] [ Designated as safety issue: No ]
time to illicit drug use events, assessed using the Reckless Behaviour Questionnaire
Frequency and Quantity of Drinking [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Problem drinking symptoms [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Assessed using an abbreviated version of the Rutger's Alcohol Problem Index

Secondary Outcome Measures:

Psychiatric symptoms (depression, panic anxiety, antisocial behaviours), coping skills, motives for drinking [ Time Frame: 2 years ] [ Designated as safety issue: No ]
Assessed using the Brief Symptom Inventory, the Reckless Behaviour Questionnaire, and the Drinking Motives Questionnaire.

Enrollment:	710
Study Start Date:	November 2003
Study Completion Date:	July 2008
Primary Completion Date:	May 2006 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Experimental: learning to cope with your impulsivity cognitive behavioural intervention teaching high impulsive youth how to manage their impulsive thinking and behaviours	Behavioral: PRE-Venture: Personality Risk Education Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.
Experimental: learning to cope with your sensation seeking cognitive-behavioural intervention teaching high sensation seeking youth how to manage their need for stimulation and excitement	Behavioral: PRE-Venture: Personality Risk Education Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.
Experimental: learning to cope with your anxiety sensitivity cognitive behavioural intervention targeting catastrophic thinking in high anxiety sensitive youth	Behavioral: PRE-Venture: Personality Risk Education Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.
Experimental: learning to manage your negative thinking cognitive behavioural intervention targeting pessimistic and negative thinking in hopeless youth	Behavioral: PRE-Venture: Personality Risk Education Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.

Detailed Description:

Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press). As these interventions target personality traits linked to risk for addictive and non-addictive psychopathology, the aim of this study is to examine the extent to which this approach is effective in preventing and/or reduce alcohol and drug misuse and concurrent psychiatric symptoms in young people.

Method: 875 Participants aged 13-16 years will be screened for personality risk in school-wide self-report assessments. Participants will be randomly assigned to a personality matched cognitive-behavioural intervention or a no-intervention control. The personality matched interventions will target four personality risk factors: negative thinking (NT), anxiety sensitivity (AS), impulsivity (IMP) and sensation seeking (SS). Outcome evaluation will occur 6, 12, 18 and 24 months post intervention. Primary outcomes will be time to onset and severity of alcohol and illicit substance use and misuse. Secondary outcome variables will include depressive symptoms, panic attack rates, reckless and antisocial behaviour. Secondary analyses involving genetic, cognitive and coping skills measures will examine moderators of treatment effects.

Hypotheses: It is expected that personality-targeted interventions will have personality-specific effects on aspects of addictive and non-addictive psychopathology to which each personality risk group is most susceptible.

Eligibility

Ages Eligible for Study:	13 Years to 16 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

secondary school student
scoring one standard deviation above the school mean on one of 4 personality dimensions.
Able to provide consent from parent/guardian for participation in the study

Exclusion Criteria:

None

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00344474

Locations

United Kingdom
Institute of Psychiatry, King's College London
London, United Kingdom, SE5 8AF

Sponsors and Collaborators

King's College London

Action on Addiction

Investigators

Principal Investigator:

Patricia J. Conrod, Ph.D.

Institute of Psychiatry

More Information

Publications:

Stewart SH, Conrod PJ, Marlatt GA, Comeau MN, Thush C, Krank M. New developments in prevention and early intervention for alcohol abuse in youths. Alcohol Clin Exp Res. 2005 Feb;29(2):278-86.

Conrod PJ, Pihl RO, Stewart SH, Dongier M. Validation of a system of classifying female substance abusers on the basis of personality and motivational risk factors for substance abuse. Psychol Addict Behav. 2000 Sep;14(3):243-56.

Conrod PJ, Stewart SH, Pihl RO, Cote S, Fontaine V, Dongier M. Efficacy of brief coping skills interventions that match different personality profiles of female substance abusers. Psychol Addict Behav. 2000 Sep;14(3):231-42.

Comeau N, Stewart SH, Loba P. The relations of trait anxiety, anxiety sensitivity, and sensation seeking to adolescents' motivations for alcohol, cigarette, and marijuana use. Addict Behav. 2001 Nov-Dec;26(6):803-25.

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Topper LR, Castellanos-Ryan N, Mackie C, Conrod PJ. Adolescent bullying victimisation and alcohol-related problem behaviour mediated by coping drinking motives over a 12 month period. Addict Behav. 2011 Jan-Feb;36(1-2):6-13. Epub 2010 Sep 24.

O'Leary-Barrett M, Mackie CJ, Castellanos-Ryan N, Al-Khudhairy N, Conrod PJ. Personality-targeted interventions delay uptake of drinking and decrease risk of alcohol-related problems when delivered by teachers. J Am Acad Child Adolesc Psychiatry. 2010 Sep;49(9):954-963.e1. Epub 2010 Jul 31.

Conrod PJ, Castellanos-Ryan N, Strang J. Brief, personality-targeted coping skills interventions and survival as a non-drug user over a 2-year period during adolescence. Arch Gen Psychiatry. 2010 Jan;67(1):85-93.

Responsible Party:	Patricia J. Conrod, King's College London
ClinicalTrials.gov Identifier:	NCT00344474 History of Changes
Other Study ID Numbers:	PAJTXVA, 229/03
Study First Received:	June 22, 2006
Last Updated:	June 24, 2011
Health Authority:	United Kingdom: National Health Service

Keywords provided by King's College London:

Prevention
Addiction
Personality
Adolescents
Binge Drinking

Alcohol Abuse
Comorbidity
Depression
Anxiety
Antisocial Behaviour

Additional relevant MeSH terms:

Depression
Depressive Disorder
Substance-Related Disorders
Panic Disorder
Alcoholism
Conduct Disorder
Behavioral Symptoms

Mood Disorders
Mental Disorders
Anxiety Disorders
Alcohol-Related Disorders
Attention Deficit and Disruptive Behavior Disorders
Mental Disorders Diagnosed in Childhood

ClinicalTrials.gov processed this record on May 16, 2013

Personality-targeted Interventions for Adolescent Alcohol Misuse (Preventure)