Personality-targeted Interventions for Adolescent Alcohol Misuse (Preventure)

This study has been completed.
Sponsor:
Collaborator:
Action on Addiction
Information provided by:
King's College London
ClinicalTrials.gov Identifier:
NCT00344474
First received: June 22, 2006
Last updated: June 24, 2011
Last verified: February 2006
  Purpose

Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press). As these interventions target personality traits linked to risk for addictive and non-addictive mental disorders, the aim of this study is to examine the extent to which this approach can prevent and/or reduce alcohol and drug misuse as well as have an impact on the onset or severity of emotional and behavioural problems in young people.


Condition Intervention Phase
Alcohol Abuse
Drug Abuse
Depression
Panic Disorder
Conduct Disorder
Behavioral: PRE-Venture: Personality Risk Education
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: A New School-based Drug Prevention Programme for Teenagers: Interventions That Target Personality Risk for Substance Abuse and Mental Illness

Resource links provided by NLM:


Further study details as provided by King's College London:

Primary Outcome Measures:
  • Time to onset and severity of drug use [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    time to illicit drug use events, assessed using the Reckless Behaviour Questionnaire

  • Frequency and Quantity of Drinking [ Time Frame: 2 years ] [ Designated as safety issue: No ]
  • Problem drinking symptoms [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    Assessed using an abbreviated version of the Rutger's Alcohol Problem Index


Secondary Outcome Measures:
  • Psychiatric symptoms (depression, panic anxiety, antisocial behaviours), coping skills, motives for drinking [ Time Frame: 2 years ] [ Designated as safety issue: No ]
    Assessed using the Brief Symptom Inventory, the Reckless Behaviour Questionnaire, and the Drinking Motives Questionnaire.


Enrollment: 710
Study Start Date: November 2003
Study Completion Date: July 2008
Primary Completion Date: May 2006 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: learning to cope with your impulsivity
cognitive behavioural intervention teaching high impulsive youth how to manage their impulsive thinking and behaviours
Behavioral: PRE-Venture: Personality Risk Education
Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.
Experimental: learning to cope with your sensation seeking
cognitive-behavioural intervention teaching high sensation seeking youth how to manage their need for stimulation and excitement
Behavioral: PRE-Venture: Personality Risk Education
Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.
Experimental: learning to cope with your anxiety sensitivity
cognitive behavioural intervention targeting catastrophic thinking in high anxiety sensitive youth
Behavioral: PRE-Venture: Personality Risk Education
Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.
Experimental: learning to manage your negative thinking
cognitive behavioural intervention targeting pessimistic and negative thinking in hopeless youth
Behavioral: PRE-Venture: Personality Risk Education
Motivational and Cognitive-Behavioural interventions targeting four personality risk factors for substance misuse. Two, 90-minute group sessions conducted at school with personality-matched peers and trained psychologists/councellors and co-facilitators.

Detailed Description:

Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press). As these interventions target personality traits linked to risk for addictive and non-addictive psychopathology, the aim of this study is to examine the extent to which this approach is effective in preventing and/or reduce alcohol and drug misuse and concurrent psychiatric symptoms in young people.

Method: 875 Participants aged 13-16 years will be screened for personality risk in school-wide self-report assessments. Participants will be randomly assigned to a personality matched cognitive-behavioural intervention or a no-intervention control. The personality matched interventions will target four personality risk factors: negative thinking (NT), anxiety sensitivity (AS), impulsivity (IMP) and sensation seeking (SS). Outcome evaluation will occur 6, 12, 18 and 24 months post intervention. Primary outcomes will be time to onset and severity of alcohol and illicit substance use and misuse. Secondary outcome variables will include depressive symptoms, panic attack rates, reckless and antisocial behaviour. Secondary analyses involving genetic, cognitive and coping skills measures will examine moderators of treatment effects.

Hypotheses: It is expected that personality-targeted interventions will have personality-specific effects on aspects of addictive and non-addictive psychopathology to which each personality risk group is most susceptible.

  Eligibility

Ages Eligible for Study:   13 Years to 16 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • secondary school student
  • scoring one standard deviation above the school mean on one of 4 personality dimensions.
  • Able to provide consent from parent/guardian for participation in the study

Exclusion Criteria:

  • None
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00344474

Locations
United Kingdom
Institute of Psychiatry, King's College London
London, United Kingdom, SE5 8AF
Sponsors and Collaborators
King's College London
Action on Addiction
Investigators
Principal Investigator: Patricia J. Conrod, Ph.D. Institute of Psychiatry
  More Information

Publications:
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Patricia J. Conrod, King's College London
ClinicalTrials.gov Identifier: NCT00344474     History of Changes
Other Study ID Numbers: PAJTXVA, 229/03
Study First Received: June 22, 2006
Last Updated: June 24, 2011
Health Authority: United Kingdom: National Health Service

Keywords provided by King's College London:
Prevention
Addiction
Personality
Adolescents
Binge Drinking
Alcohol Abuse
Comorbidity
Depression
Anxiety
Antisocial Behaviour

Additional relevant MeSH terms:
Depression
Depressive Disorder
Disease
Panic Disorder
Conduct Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders
Pathologic Processes
Anxiety Disorders
Attention Deficit and Disruptive Behavior Disorders
Mental Disorders Diagnosed in Childhood

ClinicalTrials.gov processed this record on September 18, 2014