Genetic Analysis of Hereditary Non-Syndromic Oral Clefts - Full Text View

Purpose

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

Condition
Hereditary Oral Clefts

Study Type:	Observational
Official Title:	Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

Resource links provided by NLM:

MedlinePlus related topics: Cleft Lip and Palate Genetic Testing

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	1000
Study Start Date:	June 1997

Detailed Description:

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:

A cluster of 2 or more affected first degree relatives, such as a parent and two offspring or 2 siblings, or
The occurrence of oral clefts in each of 2 generations in either the proband's paternal or maternal lineages.

EXCLUSION CRITERIA:

Families with syndromic forms of oral clefts.

Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00340626

Contacts

Contact: Joan Bailey-Wilson, Ph.D.

(443) 740-2921

jebw@nhgri.nih.gov

Locations

United States, Massachusetts
Boston University	Recruiting
Boston, Massachusetts, United States, 02118-2354
Syrian Arab Republic
IBN Al Nafees Hospital	Recruiting
Damascus, Syrian Arab Republic

Sponsors and Collaborators

National Human Genome Research Institute (NHGRI)

Investigators

Principal Investigator:

Joan Bailey-Wilson, Ph.D.

National Human Genome Research Institute (NHGRI)

More Information

Publications:

Wyszynski DF, Beaty TH, Maestri NE. Genetics of nonsyndromic oral clefts revisited. Cleft Palate Craniofac J. 1996 Sep;33(5):406-17. Review.

Zlotogora J. Genetic disorders among Palestinian Arabs: 1. Effects of consanguinity. Am J Med Genet. 1997 Feb 11;68(4):472-5.

Shprintzen RJ, Siegel-Sadewitz VL, Amato J, Goldberg RB. Anomalies associated with cleft lip, cleft palate, or both. Am J Med Genet. 1985 Apr;20(4):585-95.

ClinicalTrials.gov Identifier:	NCT00340626 History of Changes
Other Study ID Numbers:	999997035, OH97-HG-N035
Study First Received:	June 19, 2006
Last Updated:	July 27, 2012
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Linkage Analysis
Genotyping
Birth Defects
Family Study

Positional Cloning
Non-Syndronic Oral Clefts
Cleft Lip
Cleft Palate

ClinicalTrials.gov processed this record on May 19, 2013