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Isolation and Characterization of Mammary Stem Cells

This study has been completed.
Sponsor:
Collaborator:
National Institutes of Health (NIH)
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00340392
First received: June 19, 2006
Last updated: March 24, 2011
Last verified: March 2011
History of Changes
  Purpose

Background:

  • Cancer stem cells in breast cancer have been identified as a small population of tumor cells whose self-renewal mechanism is highly deregulated. This deregulation seems to be necessary for cancer to develop.
  • These cells can be identified by certain surface markers that overlap with markers associated with normal embryonic stem cells.

Objective: To isolate tumor stem cells using the same methods generally used to isolate human embryonic stem cells.

Eligibility:

  • Tissue samples will be obtained from the human cooperative network.
  • Samples will include normal tissues from individuals who have no opportunistic diseases and from individuals with cancer.

Design: Breast cancer stem cells will be isolated, grown in the laboratory and characterized.


Condition
Stem Cells

Study Type: Observational
Official Title: Isolation and Characterization of Mammary Stem Cells

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 400
Study Start Date: April 2006
Estimated Study Completion Date: March 2011
Detailed Description:

Cancers are composed of heterogeneous populations of cells with varying degrees of proliferative capacity and ability to reconstitute tumors when transplanted into nude or SCID mice.

Recently, cancer stem cells have been identified as a small population of tumor cells which possess the stem cell properties in that their self-renewal pathway is highly deregulated. This deregulation seems to be the prerequisite for the development of cancer.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria
  • INCLUSION CRITERIA:

The tissue samples will come from the human cooperative network. They have their own set of criteria. We are requesting tissue samples from individuals that are normal as well as those who have cancer.

EXCLUSION CRITERIA:

The tissue samples will come from the human cooperative tissue network and we are asking for normal samples from individuals who don't have any opportunistic diseases.

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00340392

Locations
United States, Maryland
National Cancer Institute (NCI), 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Sponsors and Collaborators
National Cancer Institute (NCI)
National Institutes of Health (NIH)
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT00340392     History of Changes
Obsolete Identifiers: NCT00900315
Other Study ID Numbers: 999906140, 06-C-N140
Study First Received: June 19, 2006
Last Updated: March 24, 2011
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Mammary Stem Cells
Breast Cancer
Cancer Stem Cells
Gene Expression Profiling

ClinicalTrials.gov processed this record on June 17, 2013