Use of the Perinatal Database and Biologic Tissue Bank at The Perinatology Research Branch (PRB) - Full Text View

Purpose

The purpose of this application is to request permission to use a bank of biological specimens and clinical information collected by the investigators prior to their joining the intramural program. The samples have been gathered under the sponsorship and approval of the Human Investigations Committees at Yale University, Wayne State University and Pennsylvania Hospital in the United States, the "Sotero del Rio Hospital", the Hospital of the "Universidad de Chile" and the "Universidad Catolica de Chile", in Chile. The investigators have generated a bank of amniotic fluid, maternal blood and urine, and fetal blood obtained at the time of delivery (from the umbilical cord and by cordocentesis), neonate's urine and sonographic examinations of the fetus, including echocardiography, stored on video-tapes. Clinical information with patient identifiers is available for these samples and sonographic examinations.

Condition
Biological Samples

Study Type:	Observational
Official Title:	Use of a Perinatal Database and Biologic Tissue Bank at the Perinatology Research Branch (PRB)

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	0
Study Start Date:	July 1995

Detailed Description:

The purpose of this application is to request permission to use a bank of biological specimens and clinical information collected by the investigators prior to their joining the intramural program. The samples have been gathered under the sponsorship and approval of the Human Investigations Committees at Yale University, Wayne State University and Pennsylvania Hospital in the United States, the "Sotero del Rio Hospital", the Hospital of the "Universidad de Chile" and the "Universidad Catolica de Chile", in Chile. The investigators have generated a bank of amniotic fluid, maternal blood and urine, and fetal blood obtained at the time of delivery (from the umbilical cord and by cordocentesis), neonate's urine and sonographic examinations of the fetus, including echocardiography, stored on video-tapes. Clinical information with patient identifiers is available for these samples and sonographic examinations.

Eligibility

Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	No

Criteria

Not listed in protocol - samples only.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00340249

Locations

United States, Maryland
National Institute of Child Health and Human Development (NICHD), 9000 Rockville
Bethesda, Maryland, United States, 20892

Sponsors and Collaborators

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Investigators

Principal Investigator:

Roberto Romero, M.D.

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

More Information

Publications:

Krebs C, Macara LM, Leiser R, Bowman AW, Greer IA, Kingdom JC. Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree. Am J Obstet Gynecol. 1996 Dec;175(6):1534-42.

Baker PN, Krasnow J, Roberts JM, Yeo KT. Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia. Obstet Gynecol. 1995 Nov;86(5):815-21.

Torry DS, Wang HS, Wang TH, Caudle MR, Torry RJ. Preeclampsia is associated with reduced serum levels of placenta growth factor. Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1539-44.

ClinicalTrials.gov Identifier:	NCT00340249 History of Changes
Other Study ID Numbers:	999995040, OH95-CH-N040
Study First Received:	June 19, 2006
Last Updated:	June 13, 2012
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Premature Rupture of the Membranes (PROM)
Preterm Delivery
In-Utero Fetal Demise
Chorioamnionitis
Spontaneous Abortion

ClinicalTrials.gov processed this record on May 16, 2013