Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2013 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00339885
First received: June 19, 2006
Last updated: March 14, 2014
Last verified: December 2013
  Purpose

The aim of the project is to positionally clone susceptibility genes for NIDDM. Patients will be ascertained in Finland from previous health surveys and hospital discharge records. Approximately 400 affected sib pairs will be collected. Families will be chosen who have, at most, one parent with NIDDM no history of IDDM. A clinical examination will be undertaken on family members and blood drawn for DNA isolation. Covariates such as body weight, blood pressure, lipid levels and urinary albumin will also be measured. The unaffected spouse and children of a subset of probands will be invited to undergo a frequently-sampled intravenous glucose tolerance test (FSIGT) to measure parameters of pancreatic function and peripheral insulin resistance (IR). A number of unrelated elderly non-diabetic subjects will also be identified to conduct a population-based association analysis.

The FSIGT analysis will be performed in Los Angeles. The DNA will be shipped to Bethesda where a total genomic scan will be performed using semi-automated fluorescence-based genotyping technology. Data from Bethesda, Los Angeles and Finland will be sent to Ann Arbor where parametric and non-parametric methods will be used to analyse both discrete traits such as NIDDM and intermediate traits like IR.


Condition
Non-Insulin Dependent Diabetes Mellitus

Study Type: Observational
Official Title: Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 60000
Study Start Date: March 1995
Detailed Description:

The Finland-United States investigation of NIDDM (FUSION) study is a long-term effort to

identify susceptibility genes for Type 2 diabetes (T2D) and associated quantitative traits. This

involves the phenotyping and DNA analysis of thousands of individuals living in Finland, utilizing a study design that was originally based on affected sib pairs. The majority of these samples have already been subjected to a genome scan using microsatellite markers and the original FUSION samples plus thousands of other cases and controls have been subjected to genome-wide association (GWA) analysis. More recently, the opportunity provided by the lowered sequencing costs have allowed targeted and/or whole genome sequencing of many of these individuals.

  Eligibility

Ages Eligible for Study:   12 Months and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • No eligibility criteria listed.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00339885

Contacts
Contact: Ann C. M. Smith (301) 435-5475 acmsmith@nhgri.nih.gov
Contact: Lori Bonnycastle, Ph.D. (301) 594-9206 lbonnyca@mail.nih.gov

Locations
United States, District of Columbia
Howard University Hospital Recruiting
Washington, District of Columbia, United States, 20060
Finland
National Public Health Institute Recruiting
Helsinki, Finland
Helsinki University Hospital District Recruiting
Helsinki, Finland
University of Kuopio Recruiting
Kuopio, Finland
Research Ethics Committee of Hospital District of Northern Savo Recruiting
Savo, Finland
Germany
Technical University Recruiting
Dresden, Germany
Norway
HUNT Research Center and Biobank Recruiting
Trondheim, Norway
University of Science and Technology (NTNU) Recruiting
Trondheim, Norway
Sponsors and Collaborators
Investigators
Principal Investigator: Lori Bonnycastle, Ph.D. National Human Genome Research Institute (NHGRI)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT00339885     History of Changes
Other Study ID Numbers: 999995030, OH95-HG-N030
Study First Received: June 19, 2006
Last Updated: March 14, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Type 2 Diabetes

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases

ClinicalTrials.gov processed this record on July 20, 2014