Neuroendocrine Dysfunction in Traumatic Brain Injury: Correlation With Cognitive Dysfunction and Repair

This study has been terminated.
Sponsor:
Information provided by:
Denver Research Institute
ClinicalTrials.gov Identifier:
NCT00336726
First received: June 13, 2006
Last updated: March 23, 2011
Last verified: December 2004
  Purpose

Traumatic Brain Injury (TBI) is a neurologic disorder cuased by physical trauma to the brain. Neuroendocrine abnormalities in these patients have been reported, including central hypogonadism within hours of the insult and eventual recovery of the hypothalamic-pituitary-gonadal axis with recovery of cognitive function to baseline. This pilot study will measure hormonal level of neuroendocine function at the time of TBI and various time points during recovery.


Condition
Traumatic Brain Injury

Study Type: Observational
Study Design: Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Denver Research Institute:

  Eligibility

Ages Eligible for Study:   21 Years to 65 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Male subjects having had a recent traumatic brain injury

Criteria

Inclusion Criteria:

  • Male subjects having had a recent traumatic brain injury.

Exclusion Criteria:

  • Currently receivng sex steroids, glucocorticoids, or have an inability to complete the neurobehavioral assessment.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00336726

Sponsors and Collaborators
Denver Research Institute
Investigators
Principal Investigator: Margaret E Wierman, MD Dept. of Veterans Affairs/University of Colorado HSC
  More Information

No publications provided

Responsible Party: Margaret Wierman, M.D., VA Medical Center
ClinicalTrials.gov Identifier: NCT00336726     History of Changes
Other Study ID Numbers: GR-735
Study First Received: June 13, 2006
Last Updated: March 23, 2011
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Brain Injuries
Brain Diseases
Central Nervous System Diseases
Craniocerebral Trauma
Nervous System Diseases
Trauma, Nervous System
Wounds and Injuries

ClinicalTrials.gov processed this record on October 20, 2014