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Measurement of Stress During Anesthesia With "Pain Detector" on Patients Receiving Atropine

The recruitment status of this study is unknown because the information has not been verified recently.
Verified April 2007 by Rikshospitalet University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Rikshospitalet University Hospital
ClinicalTrials.gov Identifier:
NCT00328900
First received: May 22, 2006
Last updated: May 31, 2012
Last verified: April 2007
  Purpose

24 patients randomly divided into two groups, one of the groups receiving atropine in addition to the planned anaesthesia. Skin conductance parameters to be compared between the two groups.


Condition Intervention
Hemorrhoids
Fissure in Ano
Drug: Administration of 0,7 mg of atropine
Device: Measurement of skin conductance with Pain detector

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Open Label
Primary Purpose: Prevention

Resource links provided by NLM:


Further study details as provided by Rikshospitalet University Hospital:

Primary Outcome Measures:
  • Number of skin conductance fluctuations

Estimated Enrollment: 24
Study Start Date: January 2006
Detailed Description:

Skin conductance (SC), in terms of numbers of skin conduction fluctuations (NSCF), amplitude and mean skin conductance level, reflect the activity in the sympathetic postganglionic cholinergic fibers which innervate the palmar and plantar sweat glands. Skin conductance, especially numbers of skin conductance fluctuations, may be a promising tool to monitor anesthesia. Atropine, an anticholinergic agent, acts as an antagonist on the muscarinic receptors of the sweat glands and inhibits their secretion in a dose-dependent way. The aim of this study was to find out to what degree SC is influenced by i.v. administration of atropine.

Study hypothesis: SC is not influenced by i.v. administration of atropine.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients in ASA-group 1-2
  • Operations (anal fissures, anal fistulas and haemorrhoids) lasting for less than one hour
  • informed consent
  • BMI <30

Exclusion Criteria:

  • Patients using any medication known to influence the autonomous nervous system
  • Patients with contraindications to atropine (e.i. fibrillation, glaucoma ect)
  • BMI >30
  • Pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00328900

Contacts
Contact: Hanne Storm, PhD +47 23074398 hanne.storm@medisin.uio.no

Locations
Norway
Ulleval University Hospital Recruiting
Oslo, Norway, 0407
Contact: Hanne Storm, PhD    +47 23074398    hanne.storm@medisin.uio.no   
Sponsors and Collaborators
Rikshospitalet University Hospital
Investigators
Study Director: Hanne Storm, PhD Rikshospitalet University Hospital
  More Information

No publications provided

Responsible Party: Hanne Storm MD.PhD, Rikshospitalet, UIO
ClinicalTrials.gov Identifier: NCT00328900     History of Changes
Other Study ID Numbers: S-03113
Study First Received: May 22, 2006
Last Updated: May 31, 2012
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Rikshospitalet University Hospital:
Galvanic skin response
Anesthesia
Atropine

Additional relevant MeSH terms:
Fissure in Ano
Hemorrhoids
Anus Diseases
Cardiovascular Diseases
Digestive System Diseases
Gastrointestinal Diseases
Intestinal Diseases
Rectal Diseases
Vascular Diseases
Atropine
Adjuvants, Anesthesia
Anti-Arrhythmia Agents
Anti-Asthmatic Agents
Autonomic Agents
Bronchodilator Agents
Cardiovascular Agents
Central Nervous System Agents
Cholinergic Agents
Cholinergic Antagonists
Molecular Mechanisms of Pharmacological Action
Muscarinic Antagonists
Mydriatics
Neurotransmitter Agents
Parasympatholytics
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Respiratory System Agents
Therapeutic Uses

ClinicalTrials.gov processed this record on November 23, 2014