Effects of Aircraft Cabin Altitude on Passenger Comfort and Discomfort
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Purpose
Commercial aircraft passengers are exposed to atmospheric pressures ranging from the pressure found at ground level to that encountered in the external environment at 8,000 feet. There is some evidence in the medical literature that symptoms of acute mountain sickness can result from ascent to altitudes of 6,300 to 10,000 feet by unacclimated persons during the first few days following ascent, probably due to the hypoxia that results from breathing air at the reduced ambient pressures at altitude. The logical hypothesis that follows is that exposure to 8,000 feet could cause hypoxia sufficient to adversely affect the comfort and well being of some commercial aircraft passengers on prolonged flights. There is insufficient data in the literature to validate this hypothesis.
Exercise at sea level and at altitude reduces arterial oxygen levels. The logical hypothesis that follows is that the combination of moderate exercise and exposure to altitude could cause hypoxia sufficiently severe to adversely affect the comfort and well being of some people and that the combined effect of exercise and altitude on comfort and well being is greater than the effect of exercise or altitude alone. Again, there is insufficient evidence in the literature to substantiate this possibility.
The purpose of this investigation is to test these hypotheses.
| Condition | Intervention |
|---|---|
|
Acute Mountain Sickness |
Procedure: Hypobaric hypoxia |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Parallel Assignment Masking: Single Blind |
| Official Title: | Investigation to Determine the Effects of Aircraft Cabin Altitudes on Passenger Comfort and Discomfort |
- ESQ IV factor scores measured at 2 hour intervals
- Oxygen Saturation measured at 2 hour intervals
| Estimated Enrollment: | 500 |
| Study Start Date: | October 2002 |
| Estimated Study Completion Date: | April 2003 |
Show Detailed Description
Eligibility| Ages Eligible for Study: | 21 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria: age 21 - 75
Exclusion Criteria:Height greater than 6'2", BMI greater than 45. Specified acute or chronic medical conditions -
-
Contacts and Locations
More Information
No publications provided by The Boeing Company
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
| ClinicalTrials.gov Identifier: | NCT00326703 History of Changes |
| Other Study ID Numbers: | Boeing001 |
| Study First Received: | May 15, 2006 |
| Last Updated: | October 16, 2006 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by The Boeing Company:
|
hypoxia hypobaric altitude |
Additional relevant MeSH terms:
|
Altitude Sickness Respiration Disorders Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 16, 2013