Tai-Chi-Chuan on Differentiation and Maturation of Dendritic Cells

This study has been completed.
Sponsor:
Information provided by:
Mackay Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00322959
First received: May 5, 2006
Last updated: September 19, 2008
Last verified: September 2008
  Purpose

Tai-Chi-Chuan (TCC), a branch of traditional Chinese martial arts, has been widely practiced since the 17th century. Recent studies have shown that TCC can improve cardiorespiratory function, muscle strength, humoral and cellular immunity, metabolic response and mental control.

Cultured monocytes from blood or bone marrow can be triggered to differentiate to myeloid dendritic cells (DC). DCs are specialized leukocytes for presenting antigens to quiescent, naive, and memory T cells, and they play pivotal roles in the induction of cell-mediated as well as humoral immune responses in vivo. Mature DCs have a capacity for initiating immunity or tolerance, which depends on their activation state.

In this study we will investigate the effect of TCC on DC differentiation in the peripheral blood obtained from the healthy donors who take part with and without TCC exercise. The distribution of various DC sub-populations (myeloid DC and plasmacytoid cell) will be analyzed by detecting surface marker expression.


Condition
Immunity

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Effect of Tai-Chi-Chuan on Differentiation and Maturation of Human Dendritic Cells

Further study details as provided by Mackay Memorial Hospital:

Enrollment: 20
Study Start Date: August 2004
Study Completion Date: November 2006
Primary Completion Date: November 2006 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   25 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

TCC practitioner and Healthy subjects as controls

Criteria

Inclusion Criteria:

  • Yang TCC practitioner who keep practicing at least 3 times a week for more than 3 years
  • Healthy subjects as controls

Exclusion Criteria:

  • Who have a history of significant cardiovascular, pulmonary, and musculoskeletal diseases
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00322959

Locations
Taiwan
Department of Medical Research, Mackay Memorial Hospital
Taipei, Taiwan, 104
Sponsors and Collaborators
Mackay Memorial Hospital
Investigators
Principal Investigator: Yu-Jen Chen, MD, PhD Mackay Memorial Hospital
  More Information

Publications:
Responsible Party: Yu-Jen Chen, Mackay Memorial Hospital
ClinicalTrials.gov Identifier: NCT00322959     History of Changes
Other Study ID Numbers: MMH-I-S-056
Study First Received: May 5, 2006
Last Updated: September 19, 2008
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Mackay Memorial Hospital:
dendritic cells
Tai-Chi-Chuan

ClinicalTrials.gov processed this record on October 23, 2014