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A Retrospective Analysis of the Predictive Potential of Pre-operative

This study has been terminated.
(The study never started.)
Sponsor:
Information provided by (Responsible Party):
Samuel C. Dudley, Jr., Emory University
ClinicalTrials.gov Identifier:
NCT00321282
First received: May 1, 2006
Last updated: September 26, 2013
Last verified: September 2013
  Purpose

Roughly thirty percent of people that undergo open heart surgery get an abnormal heart beat afterwards known as atrial fibrillation (AF). While not life threatening, this abnormal heart beat increases the likelihood of stroke and delays recovery. There are strategies to prevent post-operative AF, but they are costly and sometimes have undesirable side effects. Therefore, it would be best if we use these preventive treatments only in high risk patients.

We intend to develop a risk prediction model based on demographic and electrocardiogram (ECG) findings that will predicted who is likely to get AF. We will develop this model using data already available on patients who have undergone cardiac surgery. The development of this model will use the latest mathematical algorithms similar to those used to study genetic evolution. This type of model is capable of looking at many parameters in an unbiased way, so that only the strongest, independent predictors remain in the final model. Once, the model is developed, we will validate the model by comparing our predictions to actual outcomes previously recorded in the database.


Condition Intervention Phase
Coronary Artery Bypass
Procedure: Atrial Fibrillation
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Retrospective Analysis of the Predictive Potential of Pre-operative Data on Post-operative Atrial Fibrillation

Resource links provided by NLM:


Further study details as provided by Emory University:

Estimated Enrollment: 600
Study Start Date: February 2006
Study Completion Date: July 2007
Primary Completion Date: July 2007 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

To prevent post-operative atrial fibrillation

Exclusion Criteria:

-

  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00321282

Locations
United States, Georgia
Crawford Long Hospital
Atlanta, Georgia, United States, 30365
Emory University Hospital
Atlanta, Georgia, United States, 30322
Veterans Administration Medical Center
Decatur, Georgia, United States, 30033
Sponsors and Collaborators
Emory University
Investigators
Principal Investigator: Samuel C. Dudley, Jr., MD, PhD Atlanta VAMC/Emory University
  More Information

No publications provided

Responsible Party: Samuel C. Dudley, Jr., Principal Investigator, Emory University
ClinicalTrials.gov Identifier: NCT00321282     History of Changes
Other Study ID Numbers: 076-2006
Study First Received: May 1, 2006
Last Updated: September 26, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Emory University:
Atrial Fibrillation
Coronary Artery Bypass Graft
Risk Stratification

Additional relevant MeSH terms:
Atrial Fibrillation
Arrhythmias, Cardiac
Cardiovascular Diseases
Heart Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on November 25, 2014