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Half-Dose Intracoronary Abciximab Bolus Improves the Mortality Outcome Compared to Standard Intravenous Regimen

This study has been terminated.
Cardiologia 2 - Emodinamica - Ospedale Maggiore, Novara, Italy
Information provided by:
Azienda Sanitaria Ospedaliera Identifier:
First received: April 18, 2006
Last updated: May 15, 2006
Last verified: January 2006

The aim of our study was to demonstrate that, during a percutaneous coronary intervention, even smaller amounts of abciximab than standard dose, injected locally, could achieve a rapid thrombus resolution and clinical improvement without concomitant differences in hemorrhagic complications

Condition Intervention Phase
Coronary Disease
Myocardial Infarction
Drug: abciximab
Phase 4

Study Type: Interventional

Resource links provided by NLM:

Further study details as provided by Azienda Sanitaria Ospedaliera:

Estimated Enrollment: 84
Study Start Date: December 2004
Estimated Study Completion Date: July 2005
Detailed Description:

Patients both with acute myocardial infarction and unstable angina are prone to extensive intracoronary thrombosis, leading to acute deterioration during percutaneous coronary intervention or thrombosis of the device despite therapy. Intracoronary use of abciximab has reported favourable results. We randomly assigned 84 patients to intracoronary half abciximab bolus (group A) and to standard regimen (group B).


Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • presenting with unstable angina
  • presenting with acute myocardial infarction
  • eligibility for percutaneous coronary intervention

Exclusion Criteria:

  • presenting with cardiogenic shock
  Contacts and Locations
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Please refer to this study by its identifier: NCT00320229

Cardiologia 2 - Emodinamica - Ospedale Maggiore
Novara, Italy, 28100
Sponsors and Collaborators
Azienda Sanitaria Ospedaliera
Cardiologia 2 - Emodinamica - Ospedale Maggiore, Novara, Italy
Principal Investigator: Mara Sansa Chief Interventional Cardiology - Ospedale Maggiore - Novara - Italy
  More Information

No publications provided Identifier: NCT00320229     History of Changes
Other Study ID Numbers: ABCX-LD
Study First Received: April 18, 2006
Last Updated: May 15, 2006
Health Authority: Italy: The Italian Medicines Agency

Keywords provided by Azienda Sanitaria Ospedaliera:
Platelet Glycoprotein GPIIb-IIIa Complex
myocardial infarction

Additional relevant MeSH terms:
Coronary Artery Disease
Coronary Disease
Myocardial Infarction
Arterial Occlusive Diseases
Cardiovascular Diseases
Heart Diseases
Myocardial Ischemia
Pathologic Processes
Vascular Diseases
Hematologic Agents
Pharmacologic Actions
Platelet Aggregation Inhibitors
Therapeutic Uses processed this record on November 27, 2014